The University of California, Davis (UC Davis) received a $570,537 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The grant will support research into the molecular and cellular mechanisms of calcium dysregulation in human atrial fibroblasts and its role in promoting atrial fibrosis, a key contributing factor to atrial fibrillation. The research aims to develop quantitative frameworks for understanding the precise impact of calcium signaling on fibroblast phenotypes and atrial remodeling in atrial fibrillation. The project will combine direct measurements of calcium homeostasis regulators in human atrial fibroblasts with mathematical modeling to provide new mechanistic insights that could inform the development of novel therapeutic strategies. The award has an overall performance period from January 1, 2025 to December 31, 2028.