This $591,090 Project Grant awarded by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to determine the structural mechanisms of small-molecule activators of the cardiac calcium pump (SERCA) and to discover new non-cardiotoxic inhibitors of the cardiac sodium pump (NKA). The overarching goal is to unlock new opportunities for developing heart failure therapies targeting these clinically-relevant cardiac ion pumps.
The research involves two independent aims: (1) determining the mechanisms and interactions for small-molecule SERCA activators, and (2) discovering novel non-cardiotoxic NKA inhibitors for congestive heart failure. The award recipient is the Regents of the University of Michigan, with sub-awards to researchers at Umeå University in Sweden and Loyola University of Chicago to collaborate on portions of the proposed experiments. The award period is from Sep 1, 2024 to May 31, 2028.
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