This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $720,676 to the University of Pittsburgh to develop and evaluate a novel therapeutic strategy using ultrasound-targeted microbubble cavitation (UTMC) to deliver nitro-fatty acid (NFA) payloads. The goal is to improve ventricular recovery and mitigate complications such as microvascular obstruction (MVO) and myocardial fibrosis following myocardial infarction. The research aims to demonstrate the efficacy of UTMC with NFA-loaded microbubbles (NFAB) in enhancing perfusion, reducing inflammation, and attenuating fibrosis in animal models of ischemia-reperfusion injury and myocardial infarction. This award runs from March 2025 through December 2028 and supports a collaborative research effort led by the University of Pittsburgh.
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