Project Grant R01HL173183
- This federal Project Grant award of $429,000.00 from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) will fund a study to investigate the impact of selective vagal neuromodulation on heart failure indices. The 2-year project, with a start date of September 1, 2025, will be conducted by the University of Colorado-Denver. The research aims to better understand the neural interface by studying the effects of selective activation of cholinergic (efferent)...
- The federal Project Grant award of $726,452 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research to model intra- and inter-cellular networks involved in TRPC6-dependent cardiac fibrosis. The award aims to leverage computational methods and multi-scale experiments to better understand how TRPC6 signaling drives myofibroblast transformation and fibrosis in response to cardiac and dermal wounds. The research will be conducted by the...
- This federal Project Grant award for $726,035.00 was provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to map the vagal and spinal afferent innervation of healthy and diabetic rat hearts, as well as adapt these techniques to study diabetes-induced remodeling of nociceptive afferent innervation in human hearts. The primary objectives are to better understand the structural and functional roles of these cardiac afferent nerves, including...
- This $713,511 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research into the impact of myosin-binding protein C (MyBP-C) on myosin mobility and proteostasis in the context of hypertrophic cardiomyopathy (HCM). The University of Vermont & State Agricultural College, the awardee, will utilize innovative techniques to investigate how reduced MyBP-C levels, a common cause of HCM, may disrupt normal heart...
- This $556,295 Project Grant awarded by the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) aims to advance scientific understanding of cardiac pacemaking and sinus node dysfunction (SND) through research on "conditional pacemaker cells" within distinct specialized pacemaker cell subpopulations. The project will leverage advanced optical mapping technology to directly visualize pacemaking activities within these specialized cell...
- This federal Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $766,667 to the Augusta University Research Institute, Inc. to investigate the role of neddylation, a protein modification process, in the development of cardiovascular diseases. The research aims to determine the significance of neddylation in maintaining vascular smooth muscle cell homeostasis and overall vascular health. Key research activities include...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $194,375 Project Grant (CFDA 93.837 - Cardiovascular Diseases Research) to the University of California, Santa Barbara (UCSB) to study the impact of cardiomyopathy-driven extracellular matrix (ECM) remodeling on myocardial viscoelasticity and its effects on cardiomyocyte phenotype. The 24-month project aims to: 1) Determine how cardiomyopathy alters myocardial viscoelasticity, and 2) Assess how matrix viscoelasticity regulates...
- This federal Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $1,107,749 in funding to Invia LLC to develop deep learning tools for widely-available, inexpensive diagnosis of coronary microvascular and vasomotor dysfunction. The award commenced on September 5, 2025 and is scheduled for completion on August 31, 2027. The grant aims to foster research across basic, translational, clinical, and population sciences to...
- The University of Kansas Medical Center Research Institute, Inc. (KUMCRI) was awarded a $774,997 project grant from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) to conduct research on the contribution of medullary pre-sympathetic neurons to the progression of breathing disorders and autonomic dysfunction in heart failure with preserved ejection fraction (HFPEF). The project aims to provide in-vivo and in-vitro neuronal activity mapping of the...
- This Project Grant award of $249,000.00, provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), will fund research to investigate the calcium-dependent autoregulation of vasopressin neurons in a rodent model of heart failure. The key objectives are to test the hypothesis that impaired intracellular calcium signaling and somatodendritic release of vasopressin lead to the hyperexcitability and excess peripheral vasopressin...
This $472,511 Project Grant award from the National Heart, Lung, and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) supports research on the neural mechanisms underlying premature ventricular contraction (PVC)-induced cardiomyopathy. The primary awardee, Richmond Institute for Veterans Research (also doing business as McGuire Research Institute Inc.), will investigate how PVCs lead to neural remodeling that promotes cardiac remodeling and arrhythmias. The project aims to test hypotheses about the afferent and efferent neural mechanisms underlying PVC-induced cardiomyopathy, as well as evaluate the neuroprotective effects of the drug carvedilol. The research aims to elucidate how targeted neuromodulation of the cardiac neuraxis can prevent or reverse the detrimental cardiac effects of frequent PVCs. The award period runs from September 1, 2025 to May 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $472.5k | 8/20/25 |