Project Grant R01HL169632
- This Project Grant award from the National Science Foundation (NSF) under the Engineering program (CFDA 47.041) provides $199,992 to Boston University to develop a high-throughput electrical stimulation screening platform for assessing the long-term effects of cardiac contractility modulation (CCM) devices on engineered human heart tissue. The project will support a postdoctoral scholar co-mentored by researchers at the Food and Drug Administration (FDA) and Boston University to advance...
- The National Science Foundation awarded a $450,000 Project Grant to the George Washington University under the Engineering federal grant program (CFDA 47.041) to develop scalable heart-on-a-chip platforms. Over a three-year period from April 2022 through March 2025, the University will create automated systems integrating human heart slice culture components with sensor and actuator arrays. This will enable continuous on-chip multiparametric analysis of human cardiac physiology at the cellular...
- This Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) is supporting a collaborative research effort focused on developing an intelligent lab-on-chip device to monitor and promote the maturation of stem cell-derived cardiomyocytes. The $192,150 award to the New York Institute of Technology (NYIT) aims to create an integrated system that can non-invasively evaluate cardiomyocyte maturity in real-time and adaptively apply electrical and mechanical...
- This National Science Foundation (NSF) Engineering (CFDA 47.041) program grant, in the amount of $400,000, supports the development of a tissue-like, converged sensing platform for tracking excitation-contraction dynamics in cardiac organoids. The project aims to: Develop a scalable assembly strategy to fabricate an array of three-dimensional sensor structures using planar semiconducting graphene material, designed to detect both electrical and mechanical stimuli. Evaluate the multifunctional...
- The National Science Foundation (NSF) Engineering program awarded a $695,746 CAREER grant to The Washington University's Office of Sponsored Research Services Division to support research aimed at understanding how to grow more mature heart muscle from induced pluripotent stem cells (iPSCs) in the laboratory. The research project will investigate how combining mechanical loading and changes in energy sources can enhance the electrical maturation of iPSC-derived cardiomyocytes to better predict...
- This $262,138 Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) supports research at the University of Houston to investigate the mechanisms of cardiac fibrosis, a type of scarring in the heart that leads to impaired function. The key objectives are to: 1) determine the role of the endothelial-mesenchymal transition in cardiac fibrosis, and 2) develop a 3D cardiac fibrosis model to study tissue remodeling. The research will leverage a...
- This $100,000 Project Grant from the National Science Foundation Division of Chemical, Bioengineering, Environmental, and Transport Systems supports the development of a 3D human stem cell cardiac model for cardiac electrophysiology medical device safety assessment. Funded under the NSF Engineering program (CFDA 47.041), this award will allow the University of Maryland, College Park to create a novel in vitro model for evaluating the safety and efficacy of cardiac medical devices through January...
- Federal Project Grant Award Summary Boston Children's Hospital received an $833,594 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded August 1, 2025, with a completion date of May 31, 2029. The grant funds basic research investigating the pro-regenerative potential of PONTIN (an AAA+ ATPase protein) in cardiac tissue, with the objective of identifying druggable pathways to stimulate heart...
- Federal Project Grant Summary: More Heart Transplants Through Informed Donor Selection New York University School of Medicine received a $165,672 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 15, 2025, with completion targeted for August 31, 2030. This research initiative addresses the significant gap between heart transplant (HT) demand and supply in the United States by...
- Grant Award Summary Kennesaw State University received a $522,695 Project Grant from the National Heart, Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective September 1, 2025, through August 31, 2028. The award funds development and validation of an end-to-end generative artificial intelligence (AI) framework designed to efficiently predict biomechanical outputs of the bi-ventricular myocardium while identifying material properties and...
COORDINATED HEART STIMULATION TESTBED: A PLATFORM FOR CONTRACTILE VENTRICLE ENGINEERING - PROJECT SUMMARY HEART FAILURE, THE MAIN CLINICAL AND PUBLIC HEALTH PROBLEM, ACCOUNTS FOR 13% OF DEATHS IN THE US. ALTHOUGH TRANSPLANTATION IS CURRENTLY THE ONLY THERAPY FOR END-STAGE HEART FAILURE, THE AVAILABILITY AND COMPATIBILITY OF DONOR HEARTS CANNOT MEET THE CLINICAL DEMAND. BIOENGINEERED WHOLE HEARTS GENERATED BY USING EITHER 3D-PRINTED OR NATIVE SCAFFOLDS HOLD PROMISE TO ALLEVIATE THE DONOR ORGAN SHORTAGE. HOWEVER, EFFORTS TO BUILD A FUNCTIONAL BIOARTIFICIAL HEART CHAMBER BY USING HUMAN-INDUCED PLURIPOTENT STEM CELLS (HIPSCS) ARE STYMIED BY THE IMMATURITY OF HIPSC-DERIVED CARDIOMYOCYTES. RELIABLE INCUBATION SYSTEMS THAT DELIVER PHYSIOLOGICALLY MIMETIC STIMULATION TO TRAIN IMMATURE HEART MUSCLE CELLS AND DEVELOP HEART TISSUES ARE WARRANTED. WITHOUT CLOSING THIS TECHNOLOGICAL GAP, CARDIOVASCULAR TISSUE ENGINEERING WILL NOT ADVANCE TO ORGAN-LEVEL ENGINEERING, FORECLOSING THE CLINICAL AND DISCOVERY POTENTIAL. THE LONG-TERM GOAL OF THIS RESEARCH ENDEAVOR IS TO ENGINEER A TRANSPLANTABLE HEART BY USING HUMAN CELLS. IN THIS KATZ R01 GRANT, WE PROPOSE A NEW RESEARCH DIRECTION TO ADDRESS THE LONG-STANDING NEED FOR BIOREACTOR CULTIVATION AND STIMULATION TECHNOLOGIES COMPLETELY REIMAGINED FOR BIOARTIFICIAL ORGAN ENGINEERING. OUR CENTRAL HYPOTHESIS IS THAT INTEGRATING THE DIFFERENT MATURATION APPROACHES IN ONE AUTOMATED PLATFORM WILL ACHIEVE THE PHYSIOLOGICALLY RELEVANT LEVELS OF FUNCTION IN BIOENGINEERED LEFT VENTRICLES. THE OBJECTIVE IS TO ENGINEER A RECELLULARIZED LEFT VENTRICLE WITH A PHYSIOLOGICALLY SIGNIFICANT EJECTION FRACTION THROUGH THE INTEGRATION OF MECHANICAL, ELECTRICAL, AND METABOLIC STIMULI: ENABLE COORDINATED MECHANICAL AND ELECTRICAL STIMULATION IN A RECELLULARIZED LEFT VENTRICLE THROUGH A NOVEL MULTIPARAMETRIC BIOREACTOR DESIGN (AIM 1) AND DEVELOP A WHOLE ORGAN MEDIA COMPOSITION TO SUPPORT THE INCREASED METABOLIC DEMANDS OF LARGER BIOARTIFICIAL LEFT VENTRICLES (AIM 2). BASED ON OUR UNPARALLELED EXPERIENCE IN REGENERATIVE MEDICINE, WE WILL DEVELOP THE COORDINATED HEART STIMULATION TESTBED (CHEST) COMBINED WITH A NOVEL ARTIFICIAL OXYGEN CARRIER AND METABOLIC MEDIA SUPPLEMENTATION TAILOR-FITTED TO THE BIOPHYSICAL, BIOCHEMICAL, AND METABOLIC REQUIREMENTS OF DEVELOPING CONTRACTILE TISSUE. THE EXPECTED DELIVERABLES OF A CONTRACTILE VENTRICLE CONSTRUCT AND MULTIPARAMETRIC STIMULATION BIOREACTOR WILL VERTICALLY ADVANCE THE FIELD, PROVIDING ESSENTIAL NOVEL CONTRIBUTIONS TO THE ISSUES IMPAIRING CARDIAC TISSUE ENGINEERING FOR GENERATING BIOENGINEERED VENTRICLES. MECHANISTIC DISCOVERY AND BIOENGINEERING IMPROVEMENTS WILL ABOUND AS OTHER INVESTIGATORS CREATE STIMULATION TRAINING PROTOCOLS FOR THE HEART AND OTHER ENGINEERED ORGANS. THUS THE REALIZATION OF THIS PROJECT WILL PAVE THE WAY FOR A POTENTIAL NEW WAVE OF BREAKTHROUGHS IN CARDIAC TISSUE ENGINEERING TOWARD BUILDING A BIOARTIFICIAL HEART.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $390.9k | 5/9/25 | ||
| Not listed | $432.5k | 6/27/24 | ||
| Not listed | $404.2k | 5/24/23 | ||
| Not listed | $404.2k | 5/24/23 |