Interpregnancy as a critical period for maternal-child cardiovascular health in pediatric clinics: ancillary to young hearts

Active Project Grant Awarded Last action

Award ID
R01HL167876
Recipient
Awarding agency
Obligated
$4,962,249

Award facts

Assistance listing
93.837 Cardiovascular Diseases Research
Completion date 53% complete
Place of performance
Chicago, IL 60611, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Poor maternal cardiovascular health (CVH: behaviors + factors) in the peri-pregnancy period contributes to poor offspring CVH over the life course, especially in socially disadvantaged groups. Many interventions have targeted maternal CVH behaviors during pregnancy, but to improve offspring outcomes, targeting maternal CVH during preconception may be more effective due to critical early gestational events. However, preconception maternal CVH is understudied because half of pregnancies are unplanned, and clinical care among individuals of childbearing age is inconsistent. Pediatric clinical settings offer a novel access point for maternal preconception CVH, since >60% of births annually are to mothers who already have children. Leveraging this access to inves- tigate key timing and drivers of maternal-child CVH across the entire peri-pregnancy period (preconception, pregnancy, and postpartum) could reveal opportunities to break intergenerational cycles of cardiovascular DIS- ease and related disparities. Our long-term goal is to develop strategies that optimize CVH from the beginning of life. Our objective here is to characterize key timing and drivers of maternal-child CVH across peri-pregnancy to inform future person-centered interventions. We will leverage our young hearts study of diverse children from clinics across chicago to enroll and follow mothers who are likely to have another pregnancy, as well as FA- thers/CO-parents and subsequent offspring, and study them from preconception through postpartum. Based on our preliminary data, we hypothesize that 1) preconception is a sensitive period for the impact of maternal CVH on offspring CVH, 2) specific social and psychological factors shape maternal capacity, opportunity, and motiva- tion for healthy lifestyle and CVH, and 3) parents and clinicians desire specific intervention strategies to optimize maternal and child CVH. We will test our hypothesis via three specific aims: 1) compare the contributions of preconception, pregnancy, and postpartum maternal CVH to child outcomes; 2) map the contributions of social and psychological factors to maternal CVH; and 3) determine parents' and clinicians' preferences for intervention characteristics to optimize maternal-child CVH. We will analyze data from online surveys and electronic medical records among ~650 families to address aims 1 and 2, and we will interview ~40 mothers (TWICE), 20 fathers/CO- parents, and 30 clinicians to address aims 2 and 3. We will then integrate quantitative and qualitative findings into a theory-based logic model for change and guiding principles for intervention. Key innovations are a novel approach to access preconception, pragmatic technology-enabled cohort design, and integration of health PSY- chology theory and person-centeredness in a refined mixed-methods approach. The outcomes of this research on when to intervene, what to intervene on, and how to intervene will help direct public health resources and will provide a strong evidence base to develop novel interventions that promote optimal maternal-child CVH in DI- verse psychosocial contexts. The proposed project will thus enable significant progress toward eliminating MA- ternal-child health disparities and launching future generations of children with optimal CVH.

Transactions

Action Obligated Date
Amendment $678,382
Amendment $69,389
Amendment $624,500
Amendment $624,500
Amendment $23,054
Amendment $23,054
Amendment $23,054
Amendment $724,079
Amendment $724,079
Amendment $724,079
Original award $724,079
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Subawards

Subrecipient Amount Awarded
Northwestern University Dr. Norrina Allen will serve as the subaward PI for Northwestern University. Other Co-Investigators include Drs. Donald Lloyd-Jones, Lynn Yee, and Lucia Petito.… $565,122
Alliancechicago Rashmi Narayan, MD, FAAP is a board-certified pediatrician and Clinical Research Investigator at AllianceChicago. Dr. Narayan was formerly assistant professor… $99,868
Northwestern University Dr. Norrina Allen will serve as the subaward PI for Northwestern University. Other Co-Investigators include Drs. Donald Lloyd-Jones, Lynn Yee, and Lucia Petito.… $339,468
Alliancechicago PI responsibilities will include: • Identify and track patient recruitment. • Direct supervision of a research coordinator • Ensure that the budgetary… $71,445

Quick answers

Who received award R01HL167876?

R01HL167876 was awarded to ANN & Robert H Lurie Childrens Hospital Of Chicago by National Heart Lung and Blood Institute (National Institutes of Health) on March 1, 2024.

How much is award R01HL167876 worth?

$4,962,249 has been obligated on R01HL167876.

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