Multimodality deep phenotyping of postural orthostatic tachycardia syndrome (pots)
Active Project Grant Awarded Last action
- Award ID
- R01HL166272
- Recipient
-
The University Of Texas Southwestern Medical Center UEI YZJ6DKPM4W63 Part of University Of Texas System
- Awarding agency
-
National Heart Lung and Blood Institute
National Institutes of Health, Department of Health and Human Services
- Obligated
- $3,449,479
Award facts
- Assistance listing
- 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders
- Completion date 65% complete
- Funding agency
- National Institute of Neurological Disorders and Stroke National Institutes of Health, Department of Health and Human Services
- Place of performance
- Dallas, TX 75390, USA
Award details come from USAspending.gov.
Description
- Abstract
- Postural orthostatic tachycardia syndrome (pots) is a chronic disorder causing disabling symptoms and substantial loss of productivity. Not all pots patients are the same, and the causes and significance of different subtypes are not known. For example, some patients may have abnormal regulation of their immune system while others may have problems with the response of their muscles to activity. Exercise training has been shown to be a beneficial treatment for pots, but about 25% of patients are unable to complete the exercise program. Our research study will examine the different types of pots by systematically and comprehensively studying a large diverse group of patients. This will include careful assessment of symptoms, blood tests, and heart structure as well as a detailed analysis of the muscle response to exercise. This study will be the first to define the full picture of different pots subtypes and the relationship between these subtypes. Our studies will allow clinicians to better evaluate and individualize treatment and will guide future pots research.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $693,548 | |
| Amendment | $822,029 | |
| Amendment | $523,258 | |
| Amendment | $1,000,000 | |
| Original award | $410,644 |
Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| Ball State University | $65,377 | |
| The Leland Stanford Junior University | $525,689 | |
| Beth Israel Deaconess Medical Center, Inc. | $59,836 | |
| The Broad Institute, Inc. | $57,774 | |
| Texas Health Presbyterian Hospital Dallas | $1,725,805 |
Quick answers
Who received award R01HL166272?
R01HL166272 was awarded to The University Of Texas Southwestern Medical Center by National Heart Lung and Blood Institute (National Institutes of Health) on September 15, 2023.
How much is award R01HL166272 worth?
$3,449,479 has been obligated on R01HL166272.
Which agency awarded R01HL166272?
National Heart Lung and Blood Institute (National Institutes of Health) awarded R01HL166272, with funding from National Institute of Neurological Disorders and Stroke (National Institutes of Health).
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