Positive affect and pediatric asthma: an innovative positive psychology model to improve asthma management and health

Active Project Grant Awarded Last action

Award ID
R01HL166175
Recipient
Awarding agency
Obligated
$3,026,934

Award facts

Assistance listing
93.837 Cardiovascular Diseases Research
Completion date 66% complete
Place of performance
Orange, CA 92866, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Asthma, a leading chronic illness in childhood, can be life-threatening and is associated with a multitude of adverse outcomes. Guideline-recommended medical care including the use of daily, effective inhaled corticosteroids, has greatly improved the treatment of asthma. However, asthma remains a considerable health concern, particularly among adolescents, who often have preventive medication adherence rates as low as 50%. This poor adherence may not be surprising given that adolescence is a developmental period characterized by increased autonomy including self-managing one's health care, a skill that takes time to master. Further, stress has been shown to negatively impact asthma health in adolescents, and this could in part be due to stress' negative association with medication adherence. Thus, innovative approaches to improving adherence to preventive medication and decreasing stress are needed to promote better asthma health. Positive psychology is the study of positive experiences, positive individual traits, and supportive social networks. Positive affect (e.g., emotions such as happiness) is a major component in positive psychology and has been demonstrated in multiple peer reviewed studies to boost health in several conditions. Evidence suggests that the health enhancing effects of positive affect occur through its beneficial impact on health behaviors (such as medication adherence) and stress. Given the role of medication adherence and stress in asthma health, we expect that positive affect will benefit asthma health by increasing medication adherence and decreasing stress, as well as have direct effects on asthma health. That said, positive affect, adherence, stress, and asthma health are all dynamic in nature changing from moment to moment, but the momentary effects of and interactions among these factors have not been studied together in prior asthma literature. Testing these associations at the momentary level may help uncover nuanced relationships informing behavioral interventions that can be adaptive over time to fit not only the person but the occasion (i.e., what is happening in that moment), thus increasing intervention effectiveness for the management of asthma. Thus, the present proposal will test the associations between momentary-positive-affect and asthma health, as well as the hypothesized mechanisms behind this association, using a longitudinal burst design with momentary assessment of adolescents with moderate to severe persistent asthma. The work in this application lays the foundation for the development of adaptive behavioral interventions to better treat asthma in adolescents.

Transactions

Action Obligated Date
Amendment $562,072
Amendment $579,476
Amendment $565,206
Amendment $660,090
Original award $660,090

Subawards

Subrecipient Amount Awarded
Children's Hospital Of Orange County For the current project, which has received IRB approval, Dr. Weiss and Dr. Kamath will provide expertise via consultation in-person, over Zoom, and/or via… $55,593
Northwestern University Judy Moskowitz, PhD, MPH, Co-Investigator (1.2 calendar month years 1 & 5, 0.48CM Y2-3, 0.96 CM Y4): Dr. Moskowitz is a Professor of Medical Social Sciences… $17,307
University Of Rochester UR Co-Investigator will help finalize all protocols and will provide expertise throughout the study in the areas of subject recruitment and retention, pediatric… $43,654
University Of California Irvine UC Irvine will oversee patient recruitment at UCI-CHOC Children’s Hospital affiliated locations and will manage IRB submissions. Co-investigator, Dr. Zeev Kain,… $152,345
University Of California Irvine UC Irvine will oversee patient recruitment at UCI-CHOC Children’s Hospital affiliated locations and will manage IRB submissions. Co-investigator, Dr.… $149,298
Northwestern University Judy Moskowitz, PhD, MPH, Co-Investigator (1.2 calendar month years 1 & 5, 0.48CM Y2-3, 0.96 CM Y4): Dr. Moskowitz is a Professor of Medical Social Sciences… $17,307
University Of Rochester Jill Halterman, MD, MPH, Co-Investigator (1.8 calendar months year 1, 1.2 calendar months years 2 – 4, 1.8 calendar months year 5): Dr. Halterman is a… $43,654
Northwestern University Judy Moskowitz, PhD, MPH, Co-Investigator (1.2 calendar month years 1 & 5, 0.48CM Y2-3, 0.96 CM Y4): Dr. Moskowitz is a Professor of Medical Social Sciences… $43,269
University Of Rochester Jill Halterman, MD, MPH, Co-Investigator (1.8 calendar months year 1, 1.2 calendar months years 2 – 4, 1.8 calendar months year 5): Dr. Halterman is a… $62,957

Quick answers

Who received award R01HL166175?

R01HL166175 was awarded to Chapman University by National Heart Lung and Blood Institute (National Institutes of Health) on September 1, 2023.

How much is award R01HL166175 worth?

$3,026,934 has been obligated on R01HL166175.

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