Synergistic epidemics of non-communicable diseases, stigma, depression, and material insecurities among sexual and gender minorities living with HIV in nigeria

Active Project Grant Awarded Last action

Award ID
R01HL165686
Recipient
Awarding agency
Obligated
$7,389,211

Award facts

Assistance listing
93.837 Cardiovascular Diseases Research
Completion date 85% complete
Place of performance
Baltimore, MD 21201, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
There is an increasing burden of HIV-associated noncommunicable diseases (hivncd) globally, which often cluster among populations facing persistent social and economic inequalities. One such population is sexual and gender minorities (SGM), for whom stress resulting from discrimination leads to poorer health outcomes. Syndemic frameworks have been utilized to explain elevated HIV risk in SGM populations but have only recently been applied to study hivncd. Being an SGM is associated with real and perceived discrimination and stigmatization. As a result, SGM experience elevated levels of victimization including intimate partner violence (IPV) and subsequently, stress, depression, polysubstance use, and material insecurity. These factors are well-documented risk factors for disengagement in the continuum of care among SGM. There is a critical knowledge GAP for the development of modifiable intervention strategies, however, regarding how these syndemic factors leads to disease clustering of hivncd and promotes further inequities and vulnerabilities in low- and middle-income countries (lmic) where both HIV prevalence and social/economic barriers to accessing health care are remarkably high. In nigeria, where the university of maryland, the johns hopkins university, and the U.S. Military HIV research program have worked with SGM since 2012, 70% of SGM in the trust/RV368 study (84% men who have SEX with men and 16% self-identified as women) experience a moderate-to-severe level of stigma related to discriminatory policies, and social norms that leads to avoidance of HIV care. Prior to this proposal, we conducted a cross-sectional preliminary analysis, which suggested that stigma and depression are associated with clusters of cardiometabolic risk factors. The proposed work builds on the trust/RV368 study, the largest cohort of SGM in sub-saharan africa (SSA) and brings together a multidisciplinary team of researchers to: 1) examine association between syndemic factors and hivncd outcomes; 2) assess whether and how community-level and structural-level factors exacerbate the syndemic; and 3) determine whether the syndemic characterized for hivncd prevalence and outcomes is associated with risk of disengaging from hivncd care continua.

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Subawards

Subrecipient Amount Awarded
George Mason University This project seeks to examine population-level clustering of syndemic factors (stigma, depression, material insecurity, polysubstance use, intimate partner… $19,157
American University Synergistic epidemics of non-communicable diseases, stigma, depression, and material insecurities among sexual and gender minorities living with HIV in Nigeria $40,778
Subrecipient not on record This project seeks to examine population-level clustering of syndemic factors (stigma, depression, material insecurity, polysubstance use, intimate partner… $54,515
Institute Of Human Virology NIG Ltdgte This project seeks to examine population-level clustering of syndemic factors (stigma, depression, material insecurity, polysubstance use, intimate partner… $359,679
Institute Of Human Virology NIG Ltdgte Synergistic epidemics of non-communicable diseases, stigma, depression, and material insecurities among sexual and gender minorities living with HIV in Nigeria -$23,333
American University This project seeks to examine population-level clustering of syndemic factors (stigma, depression, material insecurity, polysubstance use, intimate partner… $40,778
Institute Of Human Virology NIG Ltdgte Synergistic epidemics of non-communicable diseases, stigma, depression, and material insecurities among sexual and gender minorities living with HIV in Nigeria $804,172
University Of Maryland, College Park Synergistic epidemics of non-communicable diseases, stigma, depression, and material insecurities among sexual and gender minorities living with HIV in Nigeria;… $109,030
George Mason University This project seeks to examine population-level clustering of syndemic factors (stigma, depression, material insecurity, polysubstance use, intimate partner… $19,157
George Mason University This project seeks to examine population-level clustering of syndemic factors (stigma, depression, material insecurity, polysubstance use, intimate partner… $38,873
American University $81,556
University Of Maryland, College Park Epidemics of Non-Communicable Diseases $103,666
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Quick answers

Who received award R01HL165686?

R01HL165686 was awarded to University Of Maryland, Baltimore by National Heart Lung and Blood Institute (National Institutes of Health) on August 1, 2022.

How much is award R01HL165686 worth?

$7,389,211 has been obligated on R01HL165686.

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