Regulation of gene transcription and alternative splicing by a long non-coding RNA
Active Project Grant Awarded Last action
- Award ID
- R01HL159086
- Recipient
-
University Of South Florida UEI NKAZLXLL7Z91 Part of The Regents Of The University Of Colorado
- Awarding agency
-
National Heart Lung and Blood Institute
National Institutes of Health, Department of Health and Human Services
- Obligated
- $4,307,481
Award facts
- Assistance listing
- 93.837 Cardiovascular Diseases Research
- Completion date 84% complete
- Originally
- Place of performance
- Tampa, FL 33602, USA
Award details come from USAspending.gov.
Description
- Abstract
- Research over the past decade has revealed the importance of long non-coding rnas (LNCRNAS) in the control of cardiac remodeling and heart failure. We have characterized a cardiac specific lncrna in the control of calcium handling in human and mouse cardiomyocytes. Knockout of this lncrna causes dysregulation of calcium handling in cardiomyocytes and impairs cardiac function. Knockout mice are susceptible to cardiac arrhythmias caused by catecholaminergic challenging and premature death. In this project, we propose to (1) determine mechanisms by which lncrna regulates gene expression at the transcription level, (2) determine how lncrna regulates gene expression at the alternative splicing level, and (3) determine cardiac protection conferred by lncrna in response to pathological stresses. The results from this project have the potential to facilitate the development of novel therapeutics for heart disease.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $0 | |
| Amendment | $505,728 | |
| Amendment | -$135,628 | |
| Amendment | $682,007 | |
| Amendment | -$546,379 | |
| Amendment | $506,434 | |
| Amendment | $506,434 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $546,379 | |
| Amendment | $546,379 | |
| Amendment | $546,379 | |
| Amendment | $574,874 | |
| Original award | $574,874 |
Show all 14
Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| The Regents Of The University Of California, San Diego | $233,429 | |
| Augusta University Research Institute, Inc. | $22,415 |
Quick answers
Who received award R01HL159086?
R01HL159086 was awarded to University Of South Florida by National Heart Lung and Blood Institute (National Institutes of Health) on September 1, 2022.
How much is award R01HL159086 worth?
$4,307,481 has been obligated on R01HL159086.
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