Project Grant R01HL135089

The National Heart, Lung, and Blood Institute (NHLBI) awarded a $743,388 Project Grant on August 15, 2025, to the Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct research examining the mechanisms by which sleep loss and circadian misalignment induce insulin resistance. The project, which extends through May 31, 2029, will establish the role of cortisol rhythm patterns in the development of...

Federal Grant Award Summary Cornell University received a $1.39 million Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate the emergence of polycystic ovary syndrome (PCOS) during adolescence. The award, effective August 1, 2025, through April 30, 2030, will support research defining the developmental trajectory of PCOS symptoms in early adolescence and...

The National Institute of Child Health and Human Development awarded $692,843 in project grant funding (CFDA 93.865: Child Health and Human Development Extramural Research) to the University of Virginia on August 15, 2025, for research investigating the role of estrogen formulation and route of delivery on skeletal outcomes in functional hypothalamic amenorrhea (FHA). The five-year study, concluding May 31, 2030, examines how different estrogen delivery methods—including combined oral...

Federal Grant Award Summary Brigham and Women's Hospital Inc. received a $1.26 million Project Grant award from the National Institute of Child Health and Human Development under the Child Health and Human Development Extramural Research program (CFDA 93.865), effective June 1, 2025, with an ultimate completion date of March 31, 2030. This research project investigates the dopaminergic regulation of KNDY (Kisspeptin/Neurokinin B/Dynorphin) neurons and their role in controlling...

This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $178,068 to support a 4-year research plan led by Dr. Susanna Mitro at Kaiser Foundation Hospitals. The project aims to clarify associations between blood pressure, antihypertensive medication use, and uterine fibroid diagnosis, as well as to test renin-angiotensin system signaling as a potential mechanism linking blood pressure and fibroid development. Key...

The National Heart, Lung, and Blood Institute (NHLBI) awarded a $833,802 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to Brigham & Women's Hospital Inc. to study the role of the epigenetic regulator Lysine Specific Demethylase 1 (LSD1) in the regulation of aldosterone and mineralocorticoid receptor pathways, and their impact on cardiovascular health. The research aims to address gaps in understanding the mechanisms underlying aldosterone and...

Federal Grant Award Summary Boston Children's Hospital received a $178,000 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), effective May 9, 2025, through April 30, 2027. The award funds research investigating the effects of maternal genetic risk factors for Polycystic Ovary Syndrome (PCOS) on birth and childhood outcomes in offspring. The research leverages...

ROMA:WOMEN Cooperative Agreement Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a Cooperative Agreement totaling $1,048,249 to Weill Medical College of Cornell University, effective September 15, 2025, through August 31, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837). This award funds the ROMA:WOMEN (Randomized Comparison of the Outcomes of Single vs Multiple Arterial Grafts Trial in Women) study, the first cardiac surgery trial dedicated...

This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $2,559,308 to examine the impact of severe pre-eclampsia on heart function in diverse racial groups of women. The project will evaluate heart function at delivery and at 6- and 12-months postpartum, as well as characterize the cardiomyopathic genetic profile of the participants. A sub-award of undisclosed amount has been issued to...

This $670,890 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports a study to determine the vascular and neural effects of chronic lower leg heating in pregnant women with obesity. The University of Texas Southwestern Medical Center is the primary awardee and will enroll 118 pregnant participants, with half receiving 16 weeks of home-based lower leg heating via water immersion and the other half in a control group. The...