Project Grant R01GM166726
- Federal Project Grant Award Summary The Oklahoma Medical Research Foundation (OMRF) received a $787,710 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) effective September 1, 2025, with a completion date of August 31, 2027. This award funds fundamental research investigating the function and regulation of DNA replication origin firing factors, specifically focusing on the recruitment and...
- The National Institute of General Medical Sciences awarded the Board of Regents of the University of Nebraska $422,125 on July 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research on chromatin remodeling mechanisms across scales. The award funds investigation into how BAF, an ATP-dependent nucleosome remodeler, partners with distinct chromatin regulatory mechanisms to establish cell type-specific gene expression programs during development and...
- The National Institute of Child Health and Human Development awarded Oklahoma Medical Research Foundation $468,875 on August 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate homologous chromosome dynamics in mouse oocytes. The research addresses aneuploidy, which occurs in 10 to 30 percent of human gametes and typically results from chromosome segregation errors during meiosis, leading to pregnancy loss or genetic disorders such as...
- The National Institute of General Medical Sciences awarded Oklahoma State University $373,960 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research on genome evolution and design in small, single-stranded DNA phages (Microviridae). The award is structured as a Project Grant with a period of performance running through August 31, 2031. Work is performed in Oklahoma City, Oklahoma. The National Institute of General Medical Sciences...
- The National Institute of General Medical Sciences awarded the University of Massachusetts Medical School $1.34 million on September 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the molecular mechanisms of histone octamer transfer activity in BAF chromatin remodeling complexes and their relationship to cancer formation and neurodevelopmental disorders. The research examines the ARID1A subunit of CBAF complexes, which is mutated in over 20...
- The Department of Health and Human Services National Institutes of Health Office of the Director awarded Oklahoma Medical Research Foundation $805,745 on July 1, 2026, under the Research Infrastructure Programs (CFDA 93.351) to develop precision genome editing tools for functional characterization of genetic variants. The award funds development of a high-throughput, cost-effective platform for in vivo functional validation of human disease-associated genetic variants using zebrafish as a...
- The National Institute of General Medical Sciences awarded the Pacific Northwest Research Institute $1,231,446 in project grant funding on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the origin and functional impact of "hidden" structural variants in rare genetic diseases. The research examines DNA structural variants including inversions, complex genomic rearrangements, mobile element insertions, and balanced...
- The National Institute of General Medical Sciences, part of the Department of Health and Human Services National Institutes of Health, awarded the University of Texas Health Science Center at San Antonio $433,976 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate molecular mechanisms of BRCA1/2-mediated genome stability maintenance. The funded research addresses homologous recombination pathways and DNA double-strand break repair in...
- The National Institute of General Medical Sciences awarded The University of Texas Health Science Center at San Antonio $433,125 on June 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research into the spatiotemporal regulation of DNA metabolism pathways. The project examines how homologous recombination proteins are selectively activated and deactivated at DNA lesions and replication fork structures, with particular focus on tyrosine...
- Federal Grant Award Summary Magee-Womens Research Institute and Foundation received a $919,914 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 9, 2025 through September 8, 2027. The research project investigates conserved and unique features regulating meiotic crossover formation—the exchange of DNA between homologous chromosomes during meiosis. The research...
The National Institute of General Medical Sciences awarded Oklahoma Medical Research Foundation $468,875 on September 4, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the role of SWI/SNF chromatin remodeling complexes in germ line transcription and nuclear organization during meiosis. The funded research addresses errors in homologous chromosome segregation during meiosis, which are the leading cause of birth defects and spontaneous pregnancy loss. The project will use imaging techniques and genetically modified mice to explore how specific subunits of PBAF, BAF, and NCBAF complexes—including PBRM1, ARID2, ARID1A, and BRD9—regulate meiotic DNA double-strand break repair, crossover formation, and chromosome association and disjunction. The work will also generate genome-wide binding profiles for these complexes and transcription machinery components in mouse spermatocytes to investigate the relationship between SWI/SNF complexes and promoters in developing gametes, and will examine how deletion of specific subunits affects the distribution and composition of chromatin features. Performance occurs at Oklahoma Medical Research Foundation in Oklahoma City, Oklahoma. The period of performance runs through April 30, 2030. OMRF, a non-profit biomedical research institute, receives approximately 75 percent of its federal funding through research grants and operates more than 50 research laboratories with over 400 staff members across aging biology, autoimmune disease, genomics, cardiovascular health, cancer mechanisms, and developmental biology.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $468.9k | 9/3/26 |