Project Grant R01GM166538
- The National Institute of General Medical Sciences awarded Sanford Research $456,500 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to study the regulation of nucleocytoplasmic compartmentalization and nuclear envelope function. The research focuses on the nuclear envelope's role in supporting critical cellular functions including genome protection and organization, segregation of transcription and translation, and cell signaling. The project will...
- The National Institute of General Medical Sciences awarded The Salk Institute for Biological Studies $515,625 on June 12, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate fundamental mechanisms of cytoskeletal dynamics and transport, with focus on how connector proteins link molecular motors to cellular cargo and facilitate transport along microtubule tracks. The research examines two primary areas: the role of spectraplakin proteins, which link...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $381,176 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop nanoscale tools for studying membrane damage and repair and enable intracellular sensing. The project will uncover how cells detect, respond to, and repair damage to their plasma and nuclear membranes, and harness these processes for intracellular sensing. Theme 1 uses...
- The National Institute of General Medical Sciences awarded The Salk Institute for Biological Studies $625,589 on July 10, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the molecular determinants that regulate cohesin-mediated loop extrusion and stability in vivo. The research examines how the cohesin complex and CTCF protein organize chromatin through loop extrusion—a process that has been observed in vitro and in preliminary cellular studies...
- The National Institute of General Medical Sciences awarded $1.677 million to Sanford Burnham Prebys Medical Discovery Institute on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate catalytic mechanisms, regulation, and anti-fibrotic roles of the TMEM2 cell surface hyaluronidase. The research focuses on understanding how TMEM2 degrades hyaluronan, a major extracellular matrix component with a rapid metabolic turnover, and explores TMEM2's...
- The National Institute of General Medical Sciences awarded Scripps Research Institute $506,000 on July 20, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to decode membrane protein folding and functional principles using designed building blocks. The research integrates protein design with biophysical experiments to clarify fundamental chemical rules and sequence-structure relationships governing how proteins interact in lipid membranes. Membrane proteins are...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $440,000 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct research on membrane-protein interactions that control mitochondrial shape and function. The research develops multiscale biophysical tools and computer simulations to integrate molecular details into models of large-scale membrane bending in mitochondria. The work addresses two problem...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $384,394 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate molecular determinants of lipid-protein recognition through computational and experimental approaches. The research integrates deep-learning, molecular dynamics simulation, and de novo protein design to characterize biophysical interactions governing binding affinity and...
- The National Institute of General Medical Sciences awarded The Leland Stanford Junior University $1.924 million on August 5, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate how nuclear mechanical properties regulate cell functions independently of gene expression. The research examines whether and how mechanical properties of the nucleus—including size, stiffness, and integrity—control essential cellular processes such as migration, proliferation,...
- The National Institute of General Medical Sciences awarded Yale University $125,000 on February 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the influences of developmental metabolic flux on physicochemical properties of the nucleus. The research focuses on how metabolic changes during cell differentiation alter mechanical properties of the nuclear envelope, with particular attention to polyamine biosynthesis. The investigator will test...
The National Institute of General Medical Sciences awarded Sanford Burnham Prebys Medical Discovery Institute $2,903,176 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the molecular mechanisms of nuclear pore complex formation. The project, titled "Molecular Basis of Nuclear Pore Formation," will define regulatory principles governing nuclear pore biogenesis in mammalian cells. The research addresses how alterations in nuclear pore number and integrity contribute to cellular aging and human disorders including Alzheimer's disease, amyotrophic lateral sclerosis, premature aging, and cancer. The work builds on a whole-genome siRNA screen that identified two unexpected pathways controlling nuclear pore assembly: lipid metabolism and RNA splicing. Aim 1 will determine how ceramides promote nuclear pore formation through membrane bending, microdomain formation, and nucleoporin recruitment. Aim 2 will examine how the splicing factor SRSF3 regulates assembly of nucleoporins, particularly NUP98/NUP96, and will investigate a novel splicing mechanism determining NUP98 localization to nuclear pores or association with the genome. Work is performed in La Jolla, California. The period of performance runs from September 1, 2026, through August 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.9m | 8/19/26 |