Project Grant R01GM164582
- The National Institute of General Medical Sciences awarded $451,000 to The University of Texas MD Anderson Cancer Center on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to dissect the role of extracellular vesicles and matrix in wound healing. The research identifies mechanisms by which fibroblasts respond to tissue injury through extracellular vesicle cargo packaging and extracellular matrix remodeling. The project uses genetically engineered...
- The National Institute of General Medical Sciences awarded the Regents of the University of Michigan $409,941 on March 5, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct research on reprogramming cells for repair of chronic wounds. The research program centers on four investigative questions about how T-cell phenotypes contribute to inflammatory dysregulation in chronic wounds, whether T-cells can be reprogrammed to mitigate inflammation and resolve...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded the University of California, Los Angeles $368,156 on June 5, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to develop UGIGEL, a gelatin-based, self-healing bioadhesive for chronic wound treatment. The award funds research to engineer and optimize UGIGEL through a one-pot Ugi four-component reaction combining gelatin, 4-formylphenylboronic acid, gallic acid, and...
- The National Institute of General Medical Sciences awarded the Board of Regents of the University of Nebraska, through its University of Nebraska Medical Center division, $415,113 under the Biomedical Research and Research Training program (CFDA 93.859) on September 1, 2026. The award funds development of nanofiber-based sutures and dressings to reduce surgical site infections, treat wound biofilms, and promote chronic wound healing. The research builds on prior findings demonstrating successful...
- The National Institute of General Medical Sciences, a component of the Department of Health and Human Services National Institutes of Health, awarded 37Degrees, Inc. $360,247 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859, assistance type: Project Grant). The award funds development of photoacoustic microscopy systems for non-destructive, three-dimensional imaging of live and incubated engineered tissue. The project addresses a critical gap in...
- The National Institute of General Medical Sciences awarded The Medical University of South Carolina $315,417 on May 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to define molecular mechanisms of hypoxia-induced fibroblast migration during wound healing. The research identifies how low-oxygen conditions rewire cytoskeletal dynamics to increase fibroblast migration into wound tissue, a rate-limiting step in scar formation. The study focuses on PIM1 kinase as a...
- The National Institute of General Medical Sciences awarded the University of Wisconsin–Madison $116,005 on May 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support molecular research on neutrophil reverse migration in wound healing. The award funds the K99 phase of a study examining neutrophil subpopulations and their role in inflammation resolution. The research identifies key neutrophil subpopulations involved in reverse migration, tracks their...
- The National Institute of General Medical Sciences awarded the University of New England $390,500 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to probe cell signaling complexity in wound healing using engineered protein materials. The recipient will investigate how a protein's molecular environment influences its function and how information flows through protein-ligand interactions using engineered proteins and protein-based materials. The work...
- The National Institute of General Medical Sciences awarded Brigham & Womens Hospital Inc. $393,800 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop GLYCOPATCH, a multifunctional trauma adhesive for life-threatening visceral organ injuries. The award supports research into a pectin-based hydrogel sealant designed to stabilize traumatic wounds and deliver site-directed bioactives including procoagulants or antibiotics in resource-limited...
- The National Institute of General Medical Sciences, a bureau of the National Institutes of Health within the Department of Health and Human Services, awarded $301,936 to the University of California, Los Angeles on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859). The award funds data-science-guided study and design of phosphoranyl radical-mediated reactions for the discovery of novel pharmaceutical compounds. The research builds a comprehensive,...
The National Institute of General Medical Sciences (part of the National Institutes of Health, Department of Health and Human Services) awarded $393,800 to the Terasaki Institute for Biomedical Innovation on September 5, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop immunomodulatory nanofibrous modular aerogels for chronic wound healing. The research addresses chronic wounds affecting approximately 6.5 million Americans by combining three engineered biomaterial components: PRG-4-derived peptides to reprogram macrophage polarization from the pro-inflammatory M1 phenotype to the pro-healing M2 phenotype; an oxygen-generating system composed of zein, calcium peroxide, and cerium oxide enabling controlled oxygen release over one month to counteract hypoxia; and porous nanofibrous microspheres designed to support granulation tissue formation and cell migration. Preliminary data in a murine model showed greater than 80 percent granulation tissue formation within 14 days using the engineered microspheres. The Terasaki Institute, a nonprofit biomedical research organization based in Woodland Hills, California, is the prime recipient. Performance will occur in Woodland Hills, California with an ultimate completion date of May 31, 2030. This award is part of NIGMS's mission to support basic research that increases understanding of biological processes and lays the foundation for advances in disease diagnosis, treatment, and prevention.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $393.8k | 9/3/26 |