Project Grant R01GM157158
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $760,083 Project Grant to The Regents of the University of Colorado, doing business as the University of Colorado-Denver, under the Cardiovascular Diseases Research program (CFDA 93.837). The grant aims to investigate the role of the protein C system in trauma-induced coagulopathy and thromboinflammation, with the goal of developing targeted therapies. The project will examine the mechanisms underlying the protein C system's dual...
- This $405,000 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), will support a research project titled "Hemorrhage and Hemorrheology - The Critical Interaction of the Erythrocyte and the Endothelium After Injury." The project aims to better understand the relationship between red blood cells and the endothelium (inner lining of blood vessels) following traumatic injury,...
- This federal Project Grant award in the amount of $311,770.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award is supporting research at Vanderbilt University to investigate the mechanisms of tissue repair, with a focus on understanding epithelial repair and basement membrane repair. The research aims to advance knowledge of how cells coordinate migration, proliferation, and...
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $151,523 to The Medical College of Wisconsin, Inc. to investigate the role of fibrinogen in regulating inflammation and thrombus resolution in acute and chronic venous thrombosis. The research aims to develop a novel RNA therapy using lipid nanoparticles to selectively reduce circulating fibrinogen levels and elucidate its impact on thromboinflammatory processes....
- This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $511,135 to the University of California, Los Angeles (UCLA) for research on the structure and biology of Tissue Factor Pathway Inhibitor-2 (TFPI-2). The key objectives of this award are to: 1) delineate the specific residues and segments of the TFPI-2 Kunitz Domain 1 (KD1) that confer protease specificity for plasmin, Factor XIa, and...
- This $249,000 project grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), aims to elucidate the epigenetic regulation of the extracellular matrix and virus-induced fibroblast activation. The research project, which will be conducted at Tufts University over a 3-year period from September 15, 2025 to September 14, 2028, seeks to advance the understanding of the molecular mechanisms...
- The University of South Florida (USF) was awarded a $749,987 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The funding, with an award date of August 15, 2023, supports research to characterize the role of a novel mechanistic pathway involving fibrinogen, sphingolipids, and caveolar transcytosis during traumatic brain injury (TBI) as an example...
- This federal Project Grant award of $423,500.00, provided by the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training program, aims to address two critical challenges related to burn sepsis: Identifying distinct immune response phenotypes after burn injury and their relation to sepsis development, in order to enable novel approaches to mitigate sepsis risk. Determining the mechanism by which elevated angiopoietin-2 (ANGPT-2) leads...
- The National Heart, Lung, and Blood Institute, under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), awarded a $391,250.00 Project Grant to Emory University to investigate the role of fibrinogen as a mediator of COVID-19-associated coagulopathy. The award, effective from March 1, 2025 to February 29, 2028, will support a series of experiments testing the hypothesis that elevated fibrinogen levels contribute to the severe coagulation issues observed in critical...
- This $750,000 federal Project Grant award from the Department of Defense's Defense Health Agency supports research by Vanderbilt University Medical Center (VUMC) on small RNAs and the heterogeneity of risk for developing systemic lupus erythematosus. The award is funded through the Military Medical Research and Development program (CFDA 12.420), which focuses on biomedical research related to military medicine. VUMC, a leading academic medical center and nonprofit healthcare provider, will...
The U.S. Department of Health and Human Services' National Institute of General Medical Sciences (NIGMS) awarded a $454,336 Project Grant to Vanderbilt University Medical Center (VUMC) to investigate the role of the fibrinolytic-inflammatory axis in severe trauma-induced adverse outcomes. The project, titled "Unraveling the Role of the Fibrinolytic-Inflammatory Axis in Severe Trauma Adverse Outcomes: From Acute Organ Dysfunction to Chronic Disability," aims to elucidate the dynamic interplay between the fibrinolytic system and the inflammatory response, focusing on neutrophil activation in early injury and sustained macrophage-driven inflammation in late-phase complications. The research, which will utilize a clinically relevant murine model of severe trauma, is funded from September 1, 2025, through June 30, 2029, and is part of the Biomedical Research and Research Training federal grant program (CFDA 93.859).
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $454.3k | 8/25/25 |