This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $349,681.00 in funding to the University of Maryland, College Park to develop novel force nanoprobes for visualizing and quantifying intracellular forces in living cells. The goal is to create a detailed map of the mechanical forces acting on the genome, which could provide critical insights into the mechanisms of mechanical...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $330,076 to Trestle Optics LLC, a small disadvantaged business in Irvine, California, to develop a photothermal microscopy platform for non-destructively monitoring metabolites in individual cells. The project aims to integrate photothermal microscopy with spatial light interference microscopy to create a high-resolution,...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $295,561 to Biosensing Instrument Inc. to develop a commercial prototype multi-functional Plasmonic Scattering Microscopy (PSM) instrument. The PSM technology enables high-throughput, label-free quantification of membrane protein binding interactions on single cells in their native microenvironment. This addresses the need for acquiring...
The National Institute of General Medical Sciences (NIGMS) awarded a $194,590 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Texas State University. The award will fund the acquisition of a Zeiss Axio Observer 7 wide-field fluorescence microscope with Apotome-3 and live-cell imaging capabilities. This new instrument will be housed in the university's Shared Resource Operations (SRO) and will directly strengthen the research programs of three...
This federal Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), is providing $1,337,953.41 to develop and disseminate an advanced 2-photon Bessel beam light sheet (2PBLS) microscopy instrument. The goal is to enable high-speed, sub-micron-resolution volumetric imaging in deep tissue, while also allowing simultaneous lifetime...
The National Institute of General Medical Sciences (NIGMS) awarded a $291,224 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the University of Chicago to develop BRAVE-EM, a new technique that combines the wavelength specificity of optical light microscopy with the spatial resolution and volume imaging of electron microscopy. This will enable simultaneous functional imaging of molecules/proteins and structural imaging of cellular and subcellular features in whole...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) in the amount of $224,388 will provide a confocal microscope to California State University, Long Beach. The confocal microscope will enable high-resolution 3D imaging of biological samples, including 3D biomaterials, microfluidics, and pancreas tissue/organoids, to support biomedical research and education activities at the...
The National Institute of General Medical Sciences (NIGMS) has awarded a $193,339 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to Trustees of Boston University to establish proof-of-concept for a new high-speed, real-time feedback-driven single particle tracking (RT-FD-SPT) fluorescence microscope with concurrent spectroscopic readout. The goal is to develop an innovative tracking approach that leverages dual stage scanners and nonlinear controllers to enable...
This $349,816 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) aims to develop a prototype instrument, software, and consumable for non-invasive identification, tagging, and downstream characterization of live cells. The product will enable researchers to study clinically relevant cell-cell interactions, which drive many challenging diseases like cancer, autoimmunity, and neurological disorders....
This Project Grant award from the National Science Foundation's Integrative Activities program (CFDA 47.083) will provide $270,000 to the University of New Mexico to develop an advanced optical microscopy system that combines breakthrough imaging techniques. The objective is to significantly improve the ability to study how proteins cluster and interact on living cell membranes, which has the potential to advance the understanding of cell signaling processes and their relation to diseases like...