A reproducible database for untargeted metabolomics data processing across laboratories

Active Project Grant Awarded Last action

Award ID
R01GM155383
Recipient
Awarding agency
Obligated
$1,538,302

Award facts

Assistance listing
93.859 Biomedical Research and Research Training
Completion date 55% complete
Place of performance
Davis, CA, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Scientific teams led by prof. Oliver fiehn (UC davis), prof. Charles evans (university of michigan) and DR. TOM metz (pacific northwest national laboratory) will develop and validate a unified, cloud-based data processing workflow and database for high resolution LC-MS/MS metabolomics and lipidomics data. This new database, LC-binbase, will serve as cornerstone to harmonize and standardize metabolomics data reports. Through both experimental and computational robustness tests, we will show that different metabolomics laboratories can generate consensus data sets if the same set of data acquisition methods are used, even if instruments from different vendors are used. This work will lead the way for next-generation metabolomics, towards faster, more reproducible and robust data processing that leads to standardized data reports and improved interpretability for biomedical researchers. To this end, we will develop algorithms to apply LC-binbase with calculated metabolite annotation confidence scores for both hydrophilic interaction- and reversed phase chromatography, and for both qtof and orbital ION trap high resolution mass spectrometers. These confidence scores will be calculated from deviations of probability distributions of experimental and predicted retention times, accurate masses, MS/MS entropy similarity scores and ION mobility data. We will validate the usability of LC-binbase reports for biomedical researchers by interlaboratory comparison studies on diverse sets of mouse organs, plus different cell types and biofluids. Data usability will be improved by a unified compound metadata list for all annotated metabolites. We will organize events and workshops to invite the scientific community to beta-test LC-binbase.

Transactions

Action Obligated Date
Amendment $501,930
Amendment $503,425
Original award $532,947

Subawards

Subrecipient Amount Awarded
Regents Of The University Of Michigan Statement of Work – University of Michigan Dr. Evans will actively participate in all the aims of the application, which share the overarching goal of… $97,079
Battelle Memorial Institute Metabolomics has matured over the past 20 years. It is now time to get to the next stage: make it standardized, harmonized and informative. Unlike for… $114,059
Regents Of The University Of Michigan Dr. Evans will actively participate in all the aims of the application, which share the overarching goal of developing standardized untargeted metabolomics… $120,120

Quick answers

Who received award R01GM155383?

R01GM155383 was awarded to University Of California, Davis by National Institute of General Medical Sciences (National Institutes of Health) on September 15, 2024.

How much is award R01GM155383 worth?

$1,538,302 has been obligated on R01GM155383.

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