Project Grant R01GM152556
Award Date
8/1/24
Completion Date
7/31/26
Dollars Obligated
$618K
Federal Agency
National Institute of General Medical Sciences
Federal Grant Program
93.859
Assistance Type
Project Grant
Place of Performance
Seattle, WA 98122, USA
Similar Awards
This $380,495.00 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to investigate the mechanisms and factors that promote aberrant DNA repair at meiotic double-strand breaks, leading to the formation of de novo structural variants in the germline. The research program, conducted by the Regents of the University of Michigan, will address how closely spaced DNA double-strand breaks...
This $616,786 Project Grant was awarded on June 1, 2025 by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award will support research conducted by The Regents of the University of California, San Francisco (UCSF) to uncover the evolutionary mechanisms driving phenotypic variation in human populations. Key areas of investigation include the effects of recessive deleterious alleles and associative...
The National Institute of General Medical Sciences (NIGMS) awarded Dartmouth College a $409,896 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to develop new statistical methods and analyses leveraging functional genomics data to understand the effects of genetic variants and their roles in diseases. The project aims to: (i) identify response expression quantitative trait loci (eQTLs), (ii) detect disease-critical cell states using single-cell chromatin...
This $1,126,290 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will fund research to uncover key details of human evolutionary history and the genetic factors influencing population diversity and complex trait prediction. The 5-year award, effective August 1, 2024, will support the development of innovative theoretical models and computational methods to analyze population genomic data from...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under CFDA 93.859 Biomedical Research and Research Training program, provides $125,000 to The Broad Institute, Inc. (Broad Institute of MIT and Harvard) to conduct research on factors shaping the genomic spectrum of structural variants. The key objectives are to: 1) determine if homology-mediated double-strand break repair uses imperfect homology (microhomology) and if this can predict tumor...
This $400,000 Project Grant award from the National Human Genome Research Institute (NHGRI) under CFDA 93.172 "Human Genome Research" will support a research program at Brigham & Women's Hospital to develop advanced computational methods for accurately identifying and genotyping structural variants within large genetic biobank datasets. The key objectives of the work are to: 1) create haplotype-informed algorithms to improve detection sensitivity and genotyping accuracy for...
The National Institute of General Medical Sciences (NIGMS) awarded a $752,078 Project Grant (CFDA 93.859 Biomedical Research and Research Training) to the University of Georgia Research Foundation, Inc. This 5-year award aims to investigate the epigenomic consequences of the breakage-fusion-bridge (BFB) cycle, a chromosome instability process observed in many cancers. The research will analyze the genomic and epigenomic changes that occur following BFB events over multiple generations using...
This $2,463,036 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports the establishment of the Center for Genomic Regulation (CGR) at the Oklahoma Medical Research Foundation (OMRF). The goal of the CGR is to build a collaborative research community focused on studies examining chromatin, DNA modifications, genome structure, and transcription - key areas of genomic regulation research. The...
This federal Project Grant award, valued at $491,366 and awarded by the National Human Genome Research Institute (NHGRI) under the Human Genome Research program (CFDA 93.172), aims to develop new algorithms for accurately mapping disease-associated genetic variants to critical target genes, especially in understudied non-European populations. The award will fund research across three key objectives: Enhancing gene-disease mapping techniques for genetic variants in diverse, understudied...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $411,250 to support research on the mechanisms and genetic consequences of break-induced replication (BIR) in mammalian cells. The 5-year project, awarded to The Trustees of Columbia University in the City of New York, aims to (1) determine how BIR is regulated at telomeres and active genomic loci, and (2) develop new...