Project Grant R01ES037260
- The University of Rochester was awarded a $1,831,848 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) on March 15, 2025. The project aims to investigate how neonatal colonization by commensal microbiota shapes the development and function of lung resident leukocytes and epithelial cells, and how disruptions to this process (e.g., through antibiotic use) contribute to poor lung health and chronic...
- This federal Project Grant award of $464,133 from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) program, supports research to study the proteome of dopaminergic neurons in an in vivo model of manganese neurotoxicity. The research aims to identify the molecular signatures and potential drug targets associated with manganese-induced neurodegeneration, which is linked to Parkinson's disease. The award recipient is the University of...
- This federal Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) program, is supporting research to investigate the genetic mechanisms underlying maladaptive respiratory responses to air pollution, specifically ozone (O3) exposure. The $671,165 award, spanning January 1, 2025 to October 31, 2029, will enable researchers at the University of North Carolina at Chapel Hill to: Profile the transcriptomes and...
- This $526,627 Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) federal grant program, supports research to investigate the mechanisms of impaired epithelial regeneration and fibrosis after silica dust inhalation. The research aims to understand why transitional alveolar epithelial cells in mouse models of silicosis and asbestosis are unable to differentiate into alveolar type 1 cells, leading to nonresolving,...
- The Project Grant award of $2,518,755 from the National Institute of Environmental Health Sciences (CFDA 93.113 Environmental Health) supports research conducted by New York University School of Medicine to investigate the mechanisms by which the carcinogen chromium(VI) and the scaffolding protein NEDD9 contribute to the development of non-small cell lung cancer. The research aims to elucidate how chronic chromium(VI) exposure impairs autophagy, leading to the upregulation of the protein p62 and...
- This $113,683 federal Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research to characterize the determinants of cellular senescence and epigenetic dysregulation caused by exposure to cigarette smoke, and their role in the development of chronic obstructive pulmonary disease (COPD). The research aims to: (1) determine the time and age-dependent effects of cigarette smoke exposure on lung cellular senescence and...
- The University of Rochester was awarded a $601,496 Project Grant by the Defense Health Agency under the Military Medical Research and Development (CFDA 12.420) federal grant program. The purpose of the grant is to provide "Mechanistic Insight into the Airborne Hazards Exposure-Related Development of Neurological Disorders." The research conducted under this 3-year grant, from August 1, 2024 to July 31, 2027, will investigate the underlying biological mechanisms by which exposure to...
- The University of North Carolina at Chapel Hill received a $3,082,011 Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) federal grant program. The goal of this 4-year project is to identify gene-environment interactions with exposure to the air pollutant ozone that contribute to respiratory diseases like asthma and COPD. The researchers will utilize genetically diverse mouse populations to discover novel...
- This federal Project Grant award of $415,250.00 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) aims to investigate how a novel type of myeloid cell, known as long-lived highly differentiated monocyte-derived cells (LDMs), regulates lung-resident memory T cells (Trm) during respiratory viral infections. The research, conducted by the University of Rochester, seeks to enhance understanding of the lung's unique immune system...
- The National Institute of Environmental Health Sciences (NIEHS) awarded a $249,000 Project Grant under the Environmental Health (CFDA 93.113) federal grant program to The Regents of the University of Colorado, doing business as the University of Colorado-Denver. The grant, titled "Learning and Living with Wildfire Smoke: Creating Clean Air Environments in Schools through Youth Participatory Action Research", aims to engage high school students in establishing schools as clean air...
The University of Rochester received a $716,066 Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) federal grant program. The award, effective September 19, 2025, supports research investigating the mechanisms of bronchiolitis obliterans (BO), a devastating lung disease associated with environmental exposures to chemicals like 2,3-butanedione (diacetyl) and 2,3-pentanedione. The research focuses on understanding how these chemical exposures induce stress in airway basal cells, the progenitor cells of the airway epithelium, and how this contributes to BO disease development. Findings from this 5-year project are expected to provide critical insights into the pathogenesis of environmentally-induced BO that can inform prevention and mitigation strategies.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $716.1k | 9/18/25 |