Prenatal and infant household air pollution exposure, the human microbiome and virome, and childhood lung function: the graphs randomized controlled trial

Active Project Grant Awarded Last action

Award ID
R01ES035791
Recipient
Awarding agency
Obligated
$2,726,186

Award facts

Assistance listing
93.113 Environmental Health
Completion date 37% complete
Place of performance
New York, NY 10029, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
In low- and middle-income countries ~2.8 billion people are exposed daily to smoke from cooking fires, termed household air pollution (HAP), resulting in an estimated 2.3M deaths and 91.4M disability adjusted life years in 2019. A large proportion of HAP-attributable deaths are due to respiratory disease over the life course. Establishment of lung health in childhood is critical to reduce risk for future respiratory disease. We propose to build on an existing pregnancy cohort in ghana - the ghana randomized air pollution and health study, or graphs - to assess how randomized early life air pollution exposure programs subsequent microbiome and virome over childhood, and how these changes are further associated with lung function and lung function growth. We will use well-established, validated methods to assess these outcomes. In the long run, our research will help build the evidence base for public health interventions to reduce HAP exposure-associated respiratory disease.

Transactions

Action Obligated Date
Amendment $118,029
Amendment $1,231,131
Original award $1,377,026

Subawards

Subrecipient Amount Awarded
Kintampo Health Research Centre The objective of the current research is to evaluate associations between household air pollution, gut microbiome and virome and lung health leveraging the… $118,029
The General Hospital Corporation Year 1: IF129091109-940002 Year 2: IF129091123-940002 As MPI on this proposal, Dr. Lai will work closely with Dr. Lee to share scientific oversight for this… $318,947
The Trustees Of Columbia University In The City Of New York Year 1: IF129091109-940002 Year 2: IF129091123-940002 The objective of the proposed research is to assess associations between household air pollution and the… $408,716
Kintampo Health Research Centre The objective of the current research is to evaluate associations between household air pollution, gut microbiome and virome and lung health leveraging the… $117,300

Quick answers

Who received award R01ES035791?

R01ES035791 was awarded to Icahn School Of Medicine At Mount Sinai by National Institute of Environmental Health Sciences (National Institutes of Health) on January 17, 2025.

How much is award R01ES035791 worth?

$2,726,186 has been obligated on R01ES035791.

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