South african manganese environmental neurotoxic effects research (SMELTER)

Active Project Grant Awarded Last action

Award ID
R01ES035388
Recipient
Awarding agency
Obligated
$2,162,171

Award facts

Assistance listing
93.113 Environmental Health
Completion date 46% complete
Place of performance
Phoenix, AZ 85013, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Manganese (MN) is a well-established neurotoxicant that likely induces neurodegeneration through inflammatory pathways. Millions of people worldwide experience high levels of environmental MN from point source emissions or associated fugitive dust. In the first five years of the smelter (south african manganese environmental neurotoxic effects research) study, we assembled a cohort of >800 black african residents, including >700 exposed to MN emissions from one of the world's largest MN smelters in meyerton, south africa. We developed and validated study assessment tools in the appropriate south african languages, measured environmental MN in meyerton and a comparable non-exposed reference community (ETHEMBALETHU), examined participants using the unified parkinson disease rating scale motor subsection part 3 (UPDRS3), and evaluated participants using targeted cognitive and mood assessments. We demonstrated that meyerton residents had markedly poorer performance in these outcomes as compared to ETHEMBALETHU residents. These neurological health effects were associated with concentrations ~100-200 NG/M3 of MN as particulate matter (PM)

Transactions

Action Obligated Date
Amendment $156,845
Amendment $417,289
Amendment $417,289
Amendment $183,548
Amendment $401,669
Amendment -$15,628
Original award $601,159

Subawards

Subrecipient Amount Awarded
Wits Health Consortium (Pty) LTD The Wits subcontractor, Dr. Gill Nelson (subcontract PI), will be responsible for hiring and training all research personnel dedicated to primary data… $340,393
The Washington University The Washington University subcontract Pl, Dr. Susan Nielsen, will be responsible for performing the primary data analysis under the supervision of Dr. Sheppard.… $465,821
University Of Washington Dr. Sheppard will assist with data analysis of the clinical and neuroimaging outcomes as well as advise on other data-related aspects of the research. She… $118,322
Wits Health Consortium (Pty) LTD The Wits subcontractor, Dr. Gill Nelson (subcontract PI), will be responsible for hiring and training all research personnel dedicated to primary data… $153,605

Quick answers

Who received award R01ES035388?

R01ES035388 was awarded to Dignity Health by National Institute of Environmental Health Sciences (National Institutes of Health) on September 1, 2024.

How much is award R01ES035388 worth?

$2,162,171 has been obligated on R01ES035388.

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