Extreme weather, air pollution, and stroke among an aging female population

Active Project Grant Awarded Last action

Award ID
R01ES033413
Recipient
Awarding agency
Obligated
$5,866,207

Award facts

Assistance listing
93.113 Environmental Health
Completion date 88% complete
Originally
Funding
  • $5,114,135.00 Federal
  • $752,072.00 Non-federal
Place of performance
Irwindale, CA 91010, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
This application is in response to the PAR-19-250: "environmentalinfluences on aging: effects of extreme weatherand disaster events on aging populations ."air pollutants are especially detrimental for aging populations; exposure to air pollution as measured by ambient particulate matter (e.g., PM2.5) has been linked to diseases that increase with age, including cardiovascular diseases (CVD) and stroke. Older women (who outnumber men 3:2) are particularly susceptible to CVD endpoints and to stroke risk in particular; stroke risk in women doubles immediately following menopause. Extreme weather events such as wildfires and prolonged drought in the last decade alone have adversely affected air pollution exposure in states such as california. A number of metropolitan counties in the state have particulate pollution levels above federal and state ambient standards, and during extreme weather events, these levels rival that of the worst cities in the world. Our overall study objective is to evaluate the intersection of extreme weather events and air pollution in an aging female population who are at increased risk for cvds, and in particular, at peak susceptibility for stroke. In AIM1, we will evaluate the acute effects from wildfire events by ascertaining stroke events within geographically affected areas based on satellite imagery. Elevated PM2.5 exposure estimates resulting from a wildfire event in the affected areas will be associated with hospitalizations (including emergency room visits) from stroke and CVD. In aim 2, we will determine the role of specific PM2.5 components in stroke risk and mortality. Employing complementary satellite- and source-based approaches, we will identify key sources of PM2.5 and its chemical constituents that are attributable to stroke. Leveraging 25-years of follow-up from the study population, this aim will permit US to delineate components of air pollution from drought and wildfire events versus other (e.g., transportation, industrial) exposures. For both aims, select CVD endpoints (e.g., myocardial infarction) will also be explored. In aim 3, we will evaluate the association between PM2.5 exposure with serum immune markers among 2000 participants whose exposures reflect a cross-section of exposure during the 2015 drought and wildfire season. This aim will inform the purported biologic underpinning for stroke and CVD risk, by key PM2.5 sources and constituents. To successfully accomplish these aims, we will leverage longitudinal data from the california teachers study, a geographically-defined population-based cohort study of 133,479 women whose 25 year follow-up spans: (a) key periods of stroke and CVD susceptibility in women, and (b) elevated levels of air pollution exposure in california where there have been prolonged periods of drought and numerous wildfires.

Transactions

Action Federal Non-federal Date
Amendment $0 $0
Amendment $679,856 $0
Amendment $589,271 $0
Amendment $529,624 $0
Amendment $529,624 $0
Amendment $640,808 $0
Amendment $640,808 $0
Amendment $0 $0
Amendment $0 $0
Amendment $0 $0
Amendment $752,072 $0
Original award $752,072 $752,072
Show all 12

Subawards

Subrecipient Amount Awarded
University Of California, Davis In the current study, Dr. Kleeman will provide exposure predictions for California residents between the years 2000-2016. The exposure dataset will include… $26,852
University Of California, LOS Angeles UCLA's work will involve the quantification of serum/plasma levels of molecules produced in immune responses, including cytokines and biomarkers of… $44,432
University Of California, San Diego This project aims at understanding the role of exposure to wildfire smoke on the risk of stroke and Cardiovascular Diseases (CVD) in the California Teach… $133,688
American Heart Association, Inc. Dr. Elkind will: 1. Provide expertise related to stroke risk factors and mechanisms 2. Adjudicate events as needed 3. Help interpret data 4. Participate in… $67,666
The Governing Council Of The University Of Toronto Co-PI, Dr. Meredith Franklin is an Associate Professor of Statistics and the Environment at the University of Toronto and will contribute her expertise on… $45,342
The Governing Council Of The University Of Toronto $45,342
University Of California, San Diego This project aims at understanding the role of exposure to wildfire smoke on the risk of stroke and Cardiovascular Diseases (CVD) in the California Teach… $43,334
University Of California, Davis In the current study, Dr. Kleeman will provide exposure predictions for California residents between the years 2000-2016. The exposure dataset will include… $44,688
American Heart Association, Inc. Dr. Elkind will: 1. Provide expertise related to stroke risk factors and mechanisms 2. Adjudicate events as needed 3. Help interpret data 4. Participate in… $34,725
University Of California, LOS Angeles UCLA's work will involve the quantification of serum/plasma levels of molecules produced in immune responses, including cytokines and biomarkers of… $21,999

Quick answers

Who received award R01ES033413?

R01ES033413 was awarded to Beckman Research Institute Of The City Of Hope by National Institute of Environmental Health Sciences (National Institutes of Health) on September 2, 2021.

How much is award R01ES033413 worth?

$5,866,207 has been obligated on R01ES033413: $5,114,135 in federal funding and $752,072 in non-federal funding.

On GovTribe

See this award's full record

  • Every transaction and subaward
  • The recipient's other awards and teaming partners
  • Similar grant awards
  • Ask GovTribe AI about this award
Try for free Login