Project Grant R01ES030365

The National Institute of Environmental Health Sciences (NIEHS) awarded a $639,686 Project Grant under the Environmental Health (CFDA 93.113) program to the University of Cincinnati. The grant will fund a longitudinal study investigating the impact of fluoride exposure during critical developmental windows, from prenatal to early childhood, on cognition, neurobehavior, and brain structure in adolescence. The study will leverage existing resources from two well-characterized birth cohorts in...

The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $5,700,915 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to the Regents of the University of Michigan. The grant will fund a multi-scale approach to develop and apply fluoride efflux inhibitors to reverse oral dysbiosis and eliminate early childhood caries (ECC). The key products and services to be delivered include: Novel, effective fluoride efflux inhibitors that potentiate the...

This federal Project Grant award, funded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to investigate the mechanisms of pulpal inflammation associated with molar hypomineralization, a prevalent enamel defect. The 5-year, $152,680 award to the ADA Forsyth Institute, Inc. (doing business as The Forsyth Institute) will support research with two specific objectives: 1) examining the role of sensory...

The University of Kansas Center for Research Inc. was awarded a $467,008 Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), to develop a novel non-invasive treatment for dental caries in children and patients with special needs. The project aims to create a biomimetic peptide-polymer interface that works synergistically with silver diamine fluoride (SDF) to arrest caries progression and...

This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support a study on the effectiveness of silver diamine fluoride (SDF) in arresting dental caries in adults. The primary aim is to determine whether teeth treated with SDF required subsequent caries-related procedures (extractions, root canals, restorations) during a 1-5 year follow-up period. The secondary aim is to assess...

This $546,350 Project Grant, awarded on January 13, 2025 by the National Institute of Environmental Health Sciences (CFDA 93.113 Environmental Health), supports research to define the neurotoxic and neurodevelopmental health risks of per- and polyfluoroalkyl substances (PFAS). The primary awardee, The Research Foundation for the State University of New York, will utilize zebrafish models to investigate PFAS uptake mechanisms, cellular impacts, and effects on neurodevelopment and behavior. A...

This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) program, will fund a study to examine the causal effects of preventive dental services and school-based dental screening requirements on children's academic achievement. The $155,500 award, effective May 1, 2025 through April 30, 2027, will leverage a unique dataset linking birth certificates, Medicaid records, and school test scores for...

The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $157,500 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to The Ohio State University to conduct research on the cellular mechanisms regulating tooth development. The research aims to determine how the signaling molecule SEMA7A influences the mineralization of dentin, elongation of tooth roots, and innervation of teeth. The study will use global and conditional SEMA7A knockout mouse...

This federal Project Grant award of $695,853 from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program supports research on the impact of prenatal exposure to per- and polyfluoroalkyl substances (PFAS) on children's development. The award will fund a collaborative effort between the Arkansas Children's Research Institute, Emory University, and the University of Kentucky Research Foundation to investigate how prenatal PFAS exposure...

This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research Federal Grant Program (CFDA 93.121), provides $690,340.00 to the University of Southern California to study the role of phosphate transporters in enamel mineralization. The research aims to understand the transcellular and intracellular movements of inorganic phosphate (Pi) and how they contribute to enamel formation. The project will utilize five...