This $553,708 Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) program, aims to advance the development of a community-led Zebrafish Toxicology Phenotype Atlas. The key products and services to be delivered include: Designing and deploying a standardized Toxicophenotype Data Model to improve data compatibility across zebrafish toxicology studies and domains. Creating a Toxicophenotype Annotation Toolkit to...
This federal Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) program, provides $159,200 to the University of California, San Diego (UCSD) to conduct research on the role of oxidation-reduction (redox) signaling in normal neurodevelopment and sensitivity to environmental exposures. The key objectives are to: Characterize redox signaling during critical stages of forebrain neurodevelopment in mice using a...
The National Institute of Environmental Health Sciences (NIEHS) awarded Xcellassay, Inc. a $306,872 Project Grant under the Environmental Health (CFDA 93.113) federal grant program. The grant funding will support the development and characterization of a hand-held, bioassay-based test strip for rapid, in-field detection of water contamination by endocrine-disrupting chemicals (EDCs). The goal is to create a 1 x 1.5 cm detection strip printed with 20 nuclear receptor sensors that can be...
The National Institute of Environmental Health Sciences (NIEHS) awarded Nexilico, Inc. a $275,765 Project Grant (CFDA 93.113 - Environmental Health) to develop a predictive computational-experimental platform to characterize microbial biotransformation of xenobiotic compounds and identify naturally occurring gut microbial strains that can mitigate xenobiotic toxicity as novel probiotics. The project aims to provide cost-effective yet accurate predictions to identify microbial species capable...
This Project Grant awarded by the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program provides $295,734 to Litron Laboratories Ltd, a for-profit biotechnology company, to develop a comprehensive hen's egg model for genotoxicity testing. The project aims to create a non-animal, metabolically-active in vitro system that can effectively assess the genotoxic risk of pharmaceuticals and industrial chemicals. Key deliverables include...
This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health federal grant program (CFDA 93.113) will fund research at Northern Kentucky University (NKU) to investigate the use of maternal and offspring exercise as a means to mitigate the developmental neurotoxicity effects of prenatal exposure to benzo[a]pyrene (BaP), a known carcinogen and environmental pollutant. The $140,000 award, which runs from September 2023 to August...
This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program provides $421,047 to the University of Toledo to study the interaction between genetic and environmental risk factors for autism and other neurodevelopmental disorders. The key objectives are to investigate how developmental exposure to the pyrethroid pesticide deltamethrin interacts with a genetic mutation in the SHANK3 gene, which is associated with...
This $900,804 Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) federal grant program supports the development and validation of an integrated microphysiological screening platform (MPS) with "virtual human" models to assess chemical toxicity. The key products and services to be delivered include: A 96-well MPS screening platform that combines elements of the awardee's commercial 48-well MPS with highly...
This $418,702 federal Project Grant awarded by the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113) will support research at Baylor University to investigate the impact of altered biotransformation pathways on the ability of Gulf killifish to adapt to legacy pollutants like polychlorinated biphenyls (PCBs) and polycyclic aromatic hydrocarbons (PAHs). The project will examine how a deletion in the aryl hydrocarbon receptor (AhR)...
This Project Grant award for $448,383 from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) federal grant program will fund research to determine the impact of maternal ingestion of cyanotoxins on the development and function of the stress axis in offspring. The primary objectives are to: 1) Determine if sub-chronic maternal exposure to the cyanotoxin microcystin-LR disrupts the development of brain regions that control the stress...