Project Grant R01EB038221
- The National Institute of Biomedical Imaging and Bioengineering awarded the University of California, Santa Barbara $1,189,496 on April 10, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop real-time, seconds-resolved measurements of amino acid homeostasis using electrochemical aptamer-based (EAB) sensors. The project will adapt EAB sensor technology—a platform invented by UCSB researchers—to measure plasma...
- The National Institute of Biomedical Imaging and Bioengineering awarded the University of Cincinnati Sponsored Research Services Division $398,400 on September 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop chemically-modified aptamer electrochemical sensors for ultra-sensitive biomonitoring. The research advances continuous biochemical monitoring technology to detect biomarkers at picomolar-to-nanomolar...
- The National Institute of Biomedical Imaging and Bioengineering awarded The Regents of the University of California, San Francisco $592,108 on September 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). UCSF will develop and validate stress-sensing microparticles that integrate deformable polymers and mechanomagnetic resonance nanotransducers to enable real-time monitoring of in vivo tissue mechanics with...
- The National Institute of Biomedical Imaging and Bioengineering awarded the Trustees of Boston University $245,250 on September 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop living microbial sensors for continuous biochemical monitoring. The project will engineer and validate a self-renewing cell cartridge that maintains bacterial viability for multiple weeks using passive nutrient diffusion and...
- The National Institute of Biomedical Imaging and Bioengineering awarded North Carolina State University $1.292803 million on June 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop new methods for generating high-performance aptamers for in vivo monitoring of small molecules. The research aims to advance nucleic-acid-based synthetic receptors that offer advantages over antibodies for molecular sensing,...
- The National Institute of Biomedical Imaging and Bioengineering awarded the University of California Santa Cruz $234,750 on August 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop a de novo binder-luciferase platform for multiplexed protein detection in Western blots and lateral flow assays. The project will replace antibody-based detection reagents with computationally designed, thermostable de novo...
- This National Science Foundation (NSF) Computer and Information Science and Engineering (CISE) Federal Grant Program (CFDA 47.070) award of $1,200,000 provides funding to the University of California, Berkeley from October 1, 2024 to September 30, 2028 to develop innovative sensing technologies that integrate DNA nanotechnology and CMOS electronics for next-generation diagnostics. The key objectives of this project grant are to: (1) develop molecular engineering techniques using DNA origami...
- The National Science Foundation (NSF) awarded a three-year, $449,999 Project Grant under their Engineering program (CFDA 47.041) to the University of Cincinnati to develop an implantable biosensor platform that can continuously monitor various biomarkers in the body for over a year. The project aims to create a new class of long-lasting aptamer-based sensors protected by robust porous oxide coatings, which would enable the first practical implantable monitoring system for managing chronic...
- The National Institutes of Health Office of the Director awarded $672,000 to the University of California, San Diego on August 24, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to develop synthetic uniRFP-based biosensors (SUBs) for real-time detection of small molecules in living systems. The award funds creation of an experimental platform and predictive machine learning algorithm that engineers the binding pocket of UNAG, a naturally occurring eel fluorescent protein, to...
- Federal Grant Award Summary The University of California Santa Cruz received a $412,276 Project Grant from the National Institute of Biomedical Imaging and Bioengineering under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), awarded September 1, 2025, with completion targeted for August 31, 2027. This award supports the development and validation of an optofluidic biosensor integrating a waveguide spectrometer for spectral...
The National Institute of Biomedical Imaging and Bioengineering awarded the University of California, Santa Barbara $582,137 on September 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop electrochemical aptamer-based sensors for long-duration, real-time molecular measurements in living tissue. The research aims to extend the in vivo operational lifespan of electrochemical aptamer-based sensors beyond their current limitation of less than 24 hours to enable continuous monitoring of drug and biomarker concentrations. Previous work demonstrated week-long operation spanning over 47,000 high-precision measurements. The project will address sensor degradation through nuclease-resistant nucleic acid backbones, high-surface-area electrodes, improved antifouling surfaces, more stable monolayers, and protective size-selective coatings. Success could enable real-time physiological monitoring, disease diagnosis and surveillance, and personalized drug dosing. Performance occurs at the University of California, Santa Barbara in Santa Barbara, California. The period of performance runs from September 1, 2026, through May 31, 2030. The award is classified as a Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $582.1k | 8/21/26 |