High-performance spect for dynamic brain imaging
Active Project Grant Awarded Last action
- Award ID
- R01EB034785
- Recipient
-
The General Hospital Corporation UEI FLJ7DQKLL226
- Awarding agency
-
National Institute of Biomedical Imaging and Bioenginering
National Institutes of Health, Department of Health and Human Services
- Obligated
- $2,462,801
Award facts
- Assistance listing
- 93.286 Discovery and Applied Research for Technological Innovations to Improve Human Health
- Completion date 80% complete
- Place of performance
- Boston, MA 02114, USA
Award details come from USAspending.gov.
Description
- Abstract
- Brain single photon emission computed tomography (SPECT) imaging has been of great importance for many clinical applications such as epilepsy, dementia, posttraumatic stress disorder, alzheimer's disease, parkinson's disease, and tumor imaging. The conventional dual-head gamma cameras (DHGCS) which have been the mainstay in nuclear imaging (specifically for cardiac screening) are not optimized for brain imaging where achieving simultaneously high resolution and high sensitivity is necessary. Depending on the collimator choice, dhgc resolution is 7-15 MM fwhm, which is not very useful to visualize fine structures of the human brain. There are several ongoing projects with the premise of improved scanner performance compared to the dhgc systems, however they are either focusing on using old detector technology and mainly improving the collimator geometry or focusing on very expensive (order of magnitude compared with the current designs) semiconductor technology which also leads to a complex system. With this application we seek to develop a portable SPECT scanner for dynamic brain imaging with ~4 MM fwhm resolution at the same sensitivity of the dhgc or 8X more sensitivity at 7 MM resolution. The backbone of the design is our enabling technology to fabricate high resolution detectors at practical cost. The proposed project will open new avenues for low dose brain SPECT imaging applications and enable longitudinal studies.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $609,498 | |
| Amendment | $610,108 | |
| Amendment | $604,714 | |
| Original award | $638,481 |
Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| Xtallized Intelligence Inc. | $305,967 |
Quick answers
Who received award R01EB034785?
R01EB034785 was awarded to The General Hospital Corporation by National Institute of Biomedical Imaging and Bioenginering (National Institutes of Health) on August 23, 2023.
How much is award R01EB034785 worth?
$2,462,801 has been obligated on R01EB034785.
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