Project Grant R01DK149422
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Pennsylvania $149,766 on August 17, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate mechanisms by which hypothalamic neurons differentiate between caloric sugars and non-caloric sweeteners. The research combines intraoral cannulation with in vivo fiber photometry to examine how orally-infused sugars and sweeteners affect hypothalamic...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Duke University $417,354 on December 11, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the role of long-lived neuropod cells in long-term food preferences and gut-brain signaling. The research addresses the mechanism by which early exposure to sugar-rich foods leads to persistent unhealthy food choices in humans. Preliminary findings identified a...
- The National Institute on Deafness and Other Communication Disorders awarded the University of California, Davis $603,750 on April 1, 2026, under the Research Related to Deafness and Communication Disorders program (CFDA 93.173) to investigate mechanisms by which sweeteners suppress bitter taste perception. The research employs two parallel strategies to address inconsistent bitterness reduction by non-sugar sweeteners. A human sensory panel using the split-tongue paradigm will test 60 healthy...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of California, Berkeley $1.332 million on September 25, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate neuropeptidergic mechanisms underlying hedonic feeding behavior. The funded research examines neurotensin signaling in the pathway connecting the lateral nucleus accumbens to the ventral tegmental area, focusing on how this neuropeptide...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Massachusetts General Hospital $158,960 on September 30, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct genetic research on taste preferences and their relationship to metabolic disease risk and GLP-1 receptor agonist response. The research will perform genome-wide association studies of five taste preferences, apply Mendelian randomization and polygenic...
- The National Institute of Diabetes and Digestive and Kidney Diseases, part of the Department of Health and Human Services National Institutes of Health, awarded Yale University $734,743 on July 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate striatal dopamine responses to nutrient consumption and their relationship to food intake behavior and obesity. The research will measure brain dopamine dynamics in people with normal and...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Brandeis University $1.541631 million on September 15, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the molecular and circuit mechanisms of sensory functions in pharyngeal enteric neurons of the nematode C. elegans as a model system for understanding interoception—the process by which organisms sense and regulate internal signals to appropriately...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Pennsylvania $808,720 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct a longitudinal randomized controlled trial examining how unhealthy food restrictions and healthy food incentives on a monthly food benefit program affect diet quality and program experiences among low-income Americans. The study will enroll 357...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Southern California $198,728 on December 17, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct research on hippocampal dopamine signaling and food-related memory with implications for obesity. The project, designated F31DK142526, investigates how dopamine—a neurotransmitter associated with reward and reward-prediction learning—influences...
- The National Institute of Diabetes and Digestive and Kidney Diseases, part of the National Institutes of Health under the Department of Health and Human Services, awarded $717,030 to the University of Virginia on May 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to uncover neural circuits controlling body weight and metabolism. The research develops and applies RAMPANT (rabies afferent mapping by poly-A nuclear transcriptomics), a novel...
The National Institute of Diabetes and Digestive and Kidney Diseases awarded Monell Chemical Senses Center $828,937 on August 1, 2026, to conduct a randomized controlled trial investigating how calories and sweet taste condition beverage brand preference and neural response. The project, titled "Parsing the Impact of Calories Versus Sweet Taste on Beverage Brand Conditioning," addresses a gap in understanding the mechanisms linking orosensory and metabolic signaling to real-world drivers of food intake such as branding and advertising. The research design tests competing theories about whether gut-brain caloric signaling operates independently of sweet taste cues or whether orosensory sweetness and gut-caloric signals integrate such that non-nutritive sweetener consumption—by uncoupling sweetness from calories—disrupts metabolic predictions and satiation signaling. The award funds a large human neuroimaging experiment to directly connect metabolic and neural mechanisms of sweetness and calories to branding sensitization and intake regulation. The funding is provided under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), which supports basic and clinical biomedical research on mechanisms underlying disease and improved prevention, diagnosis, and treatment of diabetes, digestive, and kidney diseases. Performance occurs in Philadelphia, Pennsylvania. The period of performance runs from August 1, 2026, through May 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $828.9k | 7/28/26 |