Project Grant R01DK147558
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded a $802,595 cooperative agreement to Pacific Northwest National Laboratory, a division of Battelle Memorial Institute, on May 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The recipient will conduct spatial multi-omics profiling of human pancreatic islet microenvironments to discover pathways and molecular mediators of early Type 1 Diabetes pathogenesis. The...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded $178,000 to Beckman Research Institute of the City of Hope on May 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct three-dimensional spatial and translational profiling of stress response pathways in Type 1 Diabetes. The research examines how proinflammatory cytokines activate the integrated stress response in pancreatic beta cells during early Type 1...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Beckman Research Institute of the City of Hope $8.445 million on May 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to identify circulating extracellular vesicles as biomarkers for early detection of type 1 diabetes. The recipient will isolate circulating extracellular vesicles from plasma, perform proteomic and RNA sequencing analysis on the vesicles, and conduct...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded $178,000 to Beckman Research Institute of The City of Hope on May 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate how the native pancreatic microenvironment regulates human islet cell function in health and type 1 diabetes. The research employs human pancreatic tissue slices to preserve native cellular architecture and directly compares hormone...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Benaroya Research Institute at Virginia Mason $302,000 on July 1, 2026, to develop a vascularized three-dimensional biomimetic microphysiological system (MPS) for isogenic modeling of immune-beta cell interactions in Type 1 Diabetes research. The recipient will adapt a proven perfusion-capable microfluidic skin-on-chip platform—a plexiglass-based chamber system with an open well, microchannel network, and inlet and...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Beckman Research Institute of the City of Hope $307,108 on September 15, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct basic research on alpha cell heterogeneity in Type 1 Diabetes. The funded research will investigate functional heterogeneity within pancreatic alpha cell subpopulations and their regulatory interactions with neighboring beta and delta cells...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Pittsburgh $812,862 on June 12, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to identify novel biomarkers of early progressive kidney function decline in type 1 diabetes. The research will use urinary and plasma peptidomics—analysis of synthesized peptides and protein degradation fragments—to discover prognostic markers that predict diabetic...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The Ohio State University $157,500 on May 22, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847, Project Grant R03DK147547). The recipient will conduct high-resolution multimodal imaging to define lipid alterations in the pancreas during type 1 diabetes. The work integrates imaging mass spectrometry, liquid chromatography mass spectrometry, Xenium spatial...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The University of Texas Southwestern Medical Center $799,693 on June 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847, Project Grant R01DK147004). The recipient will develop bioengineered pancreatic islet beta cells as a replacement therapy for Type 1 Diabetes. The research optimizes immune-checkpoint-engineered beta cells designed to induce long-term transplant...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), an institute of the Department of Health and Human Services National Institutes of Health, awarded $795,620 to the University of Massachusetts Medical School on July 15, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award funds development and validation of gene-editing technologies to engineer stem cell-derived islets for type 1 diabetes treatment. The research...
The National Institute of Diabetes and Digestive and Kidney Diseases awarded Battelle Memorial Institute's Pacific Northwest National Laboratory a $1.92 million Project Grant (R01DK147558) on August 11, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The recipient will identify and validate intermediate products of islet prohormone processing as blood-based mechanistic markers of islet cell dysfunction across the natural history of Type 1 diabetes. Work includes four main components: discovering prohormone processing products within pancreatic islet tissue using advanced proteomics; developing a high-throughput, multiplexed mass spectrometry-based assay for simultaneous monitoring of these products in blood circulation; examining the markers' potential as mechanistic indicators of islet cell dysfunction in alpha cells, beta cells, and delta cells; and exploring their predictive value for Type 1 diabetes progression. The research targets improved understanding of disease trajectory and assessment of treatment efficacy through minimally invasive blood-based markers. The award obligates $1,920,030 and runs from August 11, 2026, through August 10, 2028, with work performed in Richland, Washington.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.9m | 8/11/26 |