Project Grant R01DK146767
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Baylor College of Medicine $240,000 on August 27, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to develop preclinical mouse models expressing HIV proteins that replicate metabolic comorbidities observed in persons living with HIV, including obesity, cardiovascular disease, chronic kidney disease, osteoporosis, cancers, frailty, and cognitive decline. The research...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded the University of Illinois $882,709 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate adipose tissue dysfunction in simian immunodeficiency virus (SIV)-infected rhesus macaques treated with combination antiretroviral therapy (cART). The research addresses lipodystrophy and metabolic complications that affect over 75% of chronic HIV...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Tulane University $840,005 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the role of aryl hydrocarbon receptor (AHR) signaling in intestinal barrier function and inflammation during antiretroviral therapy-suppressed simian immunodeficiency virus infection. The research defines how gut AHR signaling preserves epithelial barrier...
- The National Institute of Allergy and Infectious Diseases awarded $297,000 to Texas Biomedical Research Institute on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to fund research on targeting super-enhancers to regulate HIV transcription and latency. The project, identified as R21AI203697, will define molecular mechanisms by which super-enhancer-associated long non-coding RNAs (SE-lncRNAs) regulate HIV transcription and maintain viral latency in...
- The National Institute of Allergy and Infectious Diseases awarded Texas Biomedical Research Institute $927,025 on May 11, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to evaluate IL-21-IGFC therapy for enhancing pulmonary immune reconstitution and limiting viral persistence in co-infected macaques. The research addresses incomplete immune reconstitution in individuals co-infected with HIV and tuberculosis despite antiretroviral therapy, using an established...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Northwestern University $811,941 on September 3, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to develop three-dimensional intestinal organoid models that investigate the bidirectional relationship between HIV transcription and intestinal barrier function in people living with HIV. The research uses complementary organoid platforms: patient-derived organoids isolated...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Northwestern University $794,032 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate mechanisms of intestinal barrier dysfunction in people living with HIV on antiretroviral therapy and to evaluate restoration of the glycan A1,2-fucose as a therapeutic intervention. The research addresses persistent gut leakiness and microbial translocation in...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The Regents of the University of California, San Francisco $194,076 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award funds a multi-omic investigation of the gut-liver axis in HIV-related liver disease. The project will define mechanistic and biomarker pathways along the gut-liver axis that contribute to and predict hepatic fibrosis in people...
- The National Institute of Diabetes and Digestive and Kidney Diseases, part of the National Institutes of Health within the Department of Health and Human Services, awarded $5.296987 million to the Regents of the University of Minnesota on September 16, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The recipient will investigate HIV reservoir dynamics and their association with metabolic complications in people with HIV on antiretroviral...
- The National Institute of Allergy and Infectious Diseases (NIAID), a component of the Department of Health and Human Services National Institutes of Health, awarded $824,278 to Texas Biomedical Research Institute on August 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) for Project Grant R01AI201766. The award funds comparative investigation of bacterial antigen presentation mechanisms in Mycobacterium tuberculosis and Francisella tularensis infections to...
The National Institute of Diabetes and Digestive and Kidney Diseases awarded Texas Biomedical Research Institute $905,998 on September 1, 2026, to investigate epigenetic mechanisms driving intestinal epithelial dysfunction in people living with HIV receiving antiretroviral therapy, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The research examines how aberrant DNA methylation and altered chromatin accessibility in colonic epithelium contribute to persistent gastrointestinal barrier disruption, microbial translocation, and systemic inflammation in treated HIV infection. The work uses chronically SIV-infected rhesus macaques as a model system to identify epigenetic alterations in genes regulating epithelial cell proliferation, inflammatory response, apoptosis, DNA damage response, and oxidative stress. Prior preliminary studies identified significant changes in DNA methylation of CpG islands and open chromatin accessibility in the colonic epithelium of SIV-infected macaques, and demonstrated that chronic phytocannabinoid treatment reduced these alterations and prevented dysbiosis in both ART-naïve and ART-experienced animals. The proposed studies will extend this work to characterize the degree to which DNA methylation changes regulate intestinal epithelial barrier function and assess effects on the size of the replication-competent latent gut HIV/SIV reservoir. Performance occurs in San Antonio, Texas, with a period of performance from September 1, 2026, through July 31, 2030. Texas Biomedical Research Institute, doing business as Southwest Foundation for Biomedical Research, operates the Southwest National Primate Research Center and provides non-human primate models for infectious disease research.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $906.0k | 8/26/26 |