This $820,119 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research focused on elucidating the mechanobiological functions of novel cytoskeletal structures in podocytes to reveal new therapeutic opportunities for kidney glomerular diseases. The primary research aims to better understand the mechanisms underlying podocyte homeostasis,...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $249,000.00 to the University of Chicago to conduct research on the role of m6A mRNA methylation in the aging of B-cells and its impact on diabetes. The research aims to characterize the temporal m6A landscape of aging B-cells, identify molecular targets of the m6A eraser ALKBH5 in the B-cell senescence...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) aims to discover the clinical consequences of genetic variation in the NPHS1 gene, which is associated with nephrotic syndrome and kidney disease. The $265,188 award will support research to investigate the impact of rare pathogenic NPHS1 variants and common regulatory variants on estimated glomerular filtration rate,...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $462,000 to the Albert Einstein College of Medicine in Bronx, NY to study the effect of ubiquitin D variants on kidney injury associated with the APOL1 gene in persons with HIV. The research aims to determine how specific variants of the ubiquitin D protein interact with APOL1 risk alleles to promote...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $1,504,974 to support research on the pathobiology of autoimmune-mediated diffuse podocytopathy, which causes minimal change disease and focal segmental glomerulosclerosis. The research aims to establish the role of autoimmunity in a subset of these kidney diseases, specifically by analyzing immunophenotypes,...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $949,056 to Northwestern University to study the functional roles of the DDX41 gene in the homeostasis of G quadruplexes during erythropoiesis. The research aims to dissect the molecular and cellular mechanisms of DDX41's functions, which is critical for developing targeted therapies for DDX41 mutation-related...
This Project Grant award of $117,000.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) will support a research project conducted by the Regents of the University of Michigan to identify gene regulatory networks related to hypoxia inducible factor-1A (HIF1A) in the kidney cortex and medulla. The project aims to use multiome data to validate predicted transcription factor motifs in areas of open...
This $249,000 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to elucidate the molecular mechanisms controlling hematopoietic stem cell (HSC) fate choices, including symmetric self-renewal, symmetric commitment, and asymmetric divisions. The research aims to characterize the HSC-like intermediate state controlled by m6A RNA...
This Project Grant award of $297,302 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research on the role of the apolipoprotein M (APOM)/sphingosine-1-phosphate (S1P) signaling axis in podocyte injury and glomerular diseases. The key goals are to investigate the relationship between glomerular APOM deficiency, impaired reverse cholesterol transport, and activation of S1P/S1P receptor...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) aims to investigate the role of the LIM-nebulette protein in helping podocytes (specialized kidney cells) adapt to mechanical stress. The $194,380 award, effective from December 6, 2024 to June 30, 2027, will fund research at the Icahn School of Medicine at Mount Sinai to develop a novel mechanical stretch platform and use...