Metal mixtures, epigenome, adiposity and cardiometabolic risk across early life
Active Project Grant Awarded Last action
- Award ID
- R01DK141453
- Recipient
-
Pennington Biomedical Research Center UEI MWYVQTQ32ME5
- Awarding agency
-
National Institute of Diabetes and Digestive and Kidney Diseases
National Institutes of Health, Department of Health and Human Services
- Obligated
- $1,516,787
Award facts
- Assistance listing
- 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research
- Completion date 25% complete
- Place of performance
- Baton Rouge, LA 70808, USA
Award details come from USAspending.gov.
Description
- Abstract
- /project summary in this project, we will examine prospective associations of blood metal mixtures mineral and DNA methylation (DNAM) from the prenatal period to early childhood with adiposity and cardiometabolic risk across childhood and adolescence. We will leverage extant resources from four prospective cohorts: the tiger kids in louisiana (N=342); the epoch (N=350) and healthy start (N=350) in colorado; and the generation R study (N=500) in the netherlands. The proposed study will include 1,542 children who are similar in age (4-16 years old) (discovery N=1042: tiger kids, epoch and healthy start; replication N=500: generation R study). Key elements of this proposal include directly-measured adiposity using gold standard methods (MRI and DXA), complementary information on a suite of cardiometabolic measures (fasting glucose, insulin, and lipids), and rich covariate data on lifestyle behaviors and tanner staging. Additionally, the proposed study will generate new data on biomarkers of early-life exposure to blood metals (arsenic, lead, mercury, cadmium, selenium, magnesium, iron, and zinc) and DNAM at multiple time-points from birth through childhood for all four existing cohorts. In aim 1, we will examine prospective associations of blood metal mixtures from the prenatal period to early childhood with adiposity and cardiometabolic risk across childhood and adolescence. In aim 2, we will discover and validate prospective DNAM patterns at birth and in early childhood that mark the relationship of prior metal exposure with adiposity and cardiometabolic risk across childhood and adolescence. In exploratory aim 3, we will test whether potentially modifiable lifestyle behaviors (infant feeding mode, diet quality, consumption of specific foods/nutrients, activity level) mitigate the adverse effects of early-life metal exposure on adiposity and cardiometabolic risk. If successful, our findings will inform future research on policies and programs (e.g., systems-level changes to nutrition guidelines) to mitigate exposure to toxic metal mixtures and enhance intake of nutritious metals.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $733,107 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Original award | $783,680 |
Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| The Regents Of The University Of Colorado | $411,916 | |
| Harvard Pilgrim Health Care, Inc. | $153,662 | |
| University Of Missouri System | $160,314 | |
| The Leland Stanford Junior University | $76,014 | |
| Harvard Pilgrim Health Care, Inc. | $95,935 | |
| University Of Missouri System | $80,599 | |
| The Leland Stanford Junior University | $38,321 |
Quick answers
Who received award R01DK141453?
R01DK141453 was awarded to Pennington Biomedical Research Center by National Institute of Diabetes and Digestive and Kidney Diseases (National Institutes of Health) on September 1, 2025.
How much is award R01DK141453 worth?
$1,516,787 has been obligated on R01DK141453.
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