The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $1,449,016 project grant (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) to Arizona State University to conduct a comprehensive study on microbial infections associated with the risk of islet autoimmunity and type 1 diabetes.
The project aims to leverage high-throughput protein array technologies to screen for antibodies against a wide range of viruses, bacteria, and parasites in samples from the TEDDY study - the world's largest prospective birth cohort study on environmental factors in type 1 diabetes pathogenesis. This multi-disciplinary effort will provide critical insights into the role of infectious agents in triggering and accelerating the progression of islet autoimmunity and ultimately type 1 diabetes.
As part of this project, Arizona State University has issued a $722,000 sub-award to Indiana University to support the detection of antimicrobial antibodies associated with islet autoimmunity using whole protein arrays.
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