Project Grant R01DK140395
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Massachusetts General Hospital $251,626 on April 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct basic research on c-kit receptor signaling in kidney collecting duct function. The research investigates the role of c-kit receptor signaling in modulating collecting duct epithelial cell composition and function. The project uses c-kit "sash" mice...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Cincinnati Children's Hospital Medical Center $750,253 on July 27, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to engineer human kidney organoids with functional collecting duct systems. The project, titled "Engineering Structure and Function of Human Kidney Organoids," addresses critical limitations in kidney organoid research by developing an...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Emory University $821,916 on March 20, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate mechanisms of angiotensin II signaling within kidney intercalated cells. The research examines how angiotensin II upregulates pendrin, a chloride-bicarbonate exchanger expressed on intercalated cells that modulates acid-base balance and blood pressure regulation. The...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the Veterans Medical Research Foundation of San Diego $383,098 on September 2, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The recipient will conduct research into kidney tubule dysfunction in APOL1-associated chronic kidney disease, with focus on developing and validating tubular biomarkers that capture kidney functions—nutrient reabsorption and toxin...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Duke University $1,636,543 on March 17, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the role of the ubiquitin editor A20 in regulating sodium transport and the hypertensive response through selective actions in kidney epithelial cells and tubules. The research addresses the mechanisms through which A20 suppresses inflammatory cytokines that modulate...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the Regents of the University of California, San Francisco $2,198,203 on September 24, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct research on modernizing clinical methods for assessing fluid excess removal during in-center hemodialysis treatment. The project addresses the long-standing practice of "dry weight" assessment—a trial-and-error...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Rush University Medical Center $749,087 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate sodium-independent mechanisms of edema in nephrotic syndrome. The project studies the role of circulating angiopoietin-like 4 (ANGPTL4), specifically its C-fragment, as a mediator of skin capillary endothelial permeability in nephrotic...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the Research Institute at Nationwide Children's Hospital $789,682 on August 25, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award funds research into the mechanisms by which the renal urothelium senses and responds to urinary tract obstruction and mitigates obstructive nephropathy. The project investigates how the renal urothelium undergoes remodeling during...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The Washington University $388,750 on April 23, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the structural and functional mechanisms of podocin in glomerular membrane organization and kidney disease. The research applies detergent-free, vesicle-based cryo-electron microscopy to determine the full-length structure of podocin at near-atomic resolution...
- The National Institute of Diabetes and Digestive and Kidney Diseases, an institute within the Department of Health and Human Services National Institutes of Health, awarded the Regents of the University of Michigan $690,854 on February 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award funds research to identify molecular and genetic mechanisms that determine and maintain kidney epithelial cell states in normal physiology and in...
The National Institute of Diabetes and Digestive and Kidney Diseases awarded Sanford Research $350,000 on August 5, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate molecular regulators of collecting duct remodeling and their role in water and ion homeostasis. The project examines cellular and molecular mechanisms governing the composition and function of the kidney's collecting duct, specifically the balance between principal cells and intercalated cells. The research addresses how changes in this cell type composition contribute to both adaptive responses—such as acid-base homeostasis during alkalosis—and pathological conditions, including acquired nephrogenic diabetes insipidus triggered by lithium treatment for bipolar disorder. The investigators have identified Notch1 and Notch2 signaling via HES1 as required for maintaining aquaporin-2-expressing principal cells, and will use HES1 as a molecular marker to characterize the signature of principal cell-to-intercalated cell conversion. Work is performed in Sioux Falls, South Dakota. The period of performance extends through May 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $350.0k | 8/3/26 |
GrantNumber | Description | Subgrantee | Prime Award | Dollars Obligated | Updated At |
|---|---|---|---|---|---|
CY25014EMORYS | Emory University | Project Grant R01DK140395 | $18.0k | 9/11/26 |