Project Grant R01DK140323

Award Date 9/15/24
Completion Date 6/30/29
Dollars Obligated $551K
Federal Grant Program
93.847
Assistance Type
Project Grant
Place of Performance
Los Angeles, CA 90027, USA
Similar Awards
This federal Project Grant award, valued at $516,648.00 and granted by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), is focused on investigating the role of epigenetic memory in intestinal regeneration. The research aims to examine whether intestinal stem cells (ISCs) maintain a memory of inflammatory exposure, and how this affects their subsequent regenerative capacity....
This $273,000 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research conducted by Weill Medical College of Cornell University. The research aims to investigate how nociceptor sensory neurons and neuropeptides regulate intestinal inflammation and tissue protection in the context of inflammatory bowel diseases (IBD). The project seeks to...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $1,882,623.00 to support research on the epigenetic regulation of intestinal tuft cells. The research aims to investigate how distinct components of the intestinal microbiota, through epigenetic mechanisms, calibrate tuft cell responses and regulate tuft cell development and...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $151,643 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to The Regents of the University of Colorado, doing business as the University of Colorado-Denver. The grant, awarded on April 11, 2025, supports research to design and evaluate "proteolysis targeting chimeras" (PROTACs) that can stabilize hypoxia-inducible factors (HIFs) to enhance...
This federal Project Grant award of $1,060,675.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research to investigate the role of the pattern recognition receptor AIM2 in regulating intestinal stem cell differentiation and type 2 immunity during inflammation. The research will use tissue-specific animal models, intestinal epithelial organoids, and...
This federal Project Grant award, valued at $656,001.00, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award will support a research project titled "Plasticity of Type 3 Innate Lymphoid Cells Regulated by Intestinal Microenvironment" at the University of Illinois. The key objectives are to examine the environmental factors and mechanisms...
This Project Grant award, totaling $233,600.00 and spanning September 1, 2024 to June 30, 2027, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award supports high-throughput functional analyses of genetic drivers of inflammatory bowel disease (IBD), a debilitating condition characterized by chronic inflammation and erosion of intestinal functions. The...
This Project Grant award, worth $492,409, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award aims to evaluate the role of the creatine pathway in regulating intestinal goblet cell development and its impact on the microbiome and susceptibility to colitis. Specifically, the research will investigate the contribution of glycolysis on goblet cell...
This $184,572 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research to characterize the transmural nature of ulcerative colitis (UC) and its impact on disease outcomes. The University of Chicago is the prime recipient. The research aims to: 1) Determine predictors of transmural structural alterations (TMA) to the bowel wall in UC patients;...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) will support research to investigate the regulation of CD39 expression and its influence on gamma delta intraepithelial lymphocyte (gd IEL) function in the context of inflammatory bowel disease (IBD). The $664,163 award, effective August 1, 2024 through May 31, 2028, will enable the Icahn School of Medicine at Mount Sinai to use a combination of ex vivo IEL culture, IEL/enteroid...

This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $551,112 to Children's Hospital Los Angeles (CHLA) to elucidate the role of deep crypt secretory (DCS) cells in colonic inflammation and tissue repair. The project aims to 1) determine if impaired DCS cell responses exacerbate colonic inflammation and limit tissue regeneration, 2) define the function of activated DCS cells in the colon, and 3) identify the cellular mechanisms regulating DCS cell population shifts and activation in response to colitis. This research could identify new therapeutic targets for inflammatory bowel disease and promote intestinal health. The award period runs from September 15, 2024 to June 30, 2029.

Generated 7/1/25, 3:34 AM