This federal Project Grant award of $706,199 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research to uncover the mechanisms of NAD depletion in obesity-induced pancreatic beta cell dysfunction and test strategies to restore beta cell mass and function in type 2 diabetes models. The award aims to define changes in NAD biosynthesis and degradation pathways...
This federal Project Grant award of $444,867.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to investigate the role of the UPR transducer XBP1 in pancreatic beta cell survival and function under metabolic stress. The research will use a novel mouse model to elucidate the pathological role of XBP1s in beta cell integrity under metabolic stress, in order to...
This Project Grant award of $847,746 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research to investigate the role of the UPR transducer XBP1 in pancreatic beta cell survival and function under metabolic stress. The research aims to elucidate the impact of XBP1S overexpression on beta cell integrity and the potential mechanisms underlying dynamic beta cell...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $1,349,491 to The Trustees of the University of Pennsylvania to conduct research on reprogramming glutamine metabolism in pancreatic beta cells. The research aims to uncover the mechanisms by which the transaminase GPT2 promotes beta cell dysfunction and death, and elucidate how GPT2...
This Project Grant award, ID R01DK140088, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The $641,794 grant awarded to the Beckman Research Institute of the City of Hope will fund research to elucidate the mechanisms that protect pancreatic beta cells from DNA damage during growth and adaptation, in order to maintain beta cell homeostasis and prevent beta...
This $126,480 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) supports research at the University of California, Davis to investigate the role of the signaling protein 14-3-3-z in regulating communication between alpha and beta cells in the pancreatic islet. The goal is to shed light on new mechanisms underlying islet cell crosstalk and its impact on islet function, which could open new avenues for understanding and treating type 2...
This Project Grant award, identified as R01DK142414, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) to the Weill Medical College of Cornell University. The $1,123,786 award, effective September 19, 2024 through June 30, 2029, supports research to systematically evaluate the molecular cascade involving Type 2 Diabetes (T2D) effector genes, RFX3/6, and T2D variants in human islet cell...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) provides $1,948,235 to Duke University to conduct research on alpha-to-beta cell communication and its role in insulin secretion and glucose homeostasis. The project will utilize preclinical studies in human islets as well as clinical studies in human subjects to investigate how alpha...
This federal Project Grant award of $248,915.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research aimed at "Unravelling the Role of Epigenetics and Cytokines in Type 2 Diabetes among African-Ancestry Populations." The key objectives are to infer causal relationships between lifestyle factors, genetic regulatory...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) provides $174,368 to the Regents of the University of Michigan to support a research project focused on understanding the role of the LRRK2 kinase in pancreatic beta cell responses to inflammatory damage. The goal is to gain insights into the molecular mechanisms that govern beta cell survival under inflammatory conditions, which could inform new therapeutic approaches for treating...