Project Grant R01DK125251

The National Institute on Aging (NIA) awarded a $489,509 Project Grant (CFDA 93.866 - Aging Research) to the Magee-Womens Research Institute And Foundation to conduct research on steroid hormone pathways regulating benign prostate hyperplasia (BPH) and lower urinary tract symptoms (LUTS) associated with aging. The 2-year project aims to: Identify proteins and pathways involved in promoting smooth muscle relaxation and bladder voiding that are dysregulated in aged mouse prostate models and...

This $598,609 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to clinically evaluate mechanisms of resistance to the drug finasteride, commonly used to manage benign prostatic hyperplasia (BPH) and associated lower urinary tract symptoms (LUTS). The primary objectives are to: (1) assess the efficacy of combination therapy (5α-reductase...

This $511,084 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to study the mechanisms of non-responsiveness to steroid 5a-reductase inhibitors (5ARIs) for the treatment of benign prostatic hyperplasia (BPH). The key objectives are to: 1) Elucidate that a specific luminal epithelial-2 (LE2) cell population is resistant to...

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $897,666 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to Old Dominion University (ODU) to investigate the role of lipid accumulation and foam cells in benign prostate disease. The research aims to elucidate the underlying pathogenesis of benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS) in order to develop novel...

This $629,250 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research to examine the role of hyaluronic acid (HA) in the pathology and symptoms of benign prostatic hyperplasia (BPH). The research team at Augusta University Research Institute, Inc. will characterize HA and related molecules in BPH tissues, investigate why HA is elevated in BPH, and determine HA's...

This $318,488 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to develop and test optimized oral formulations to treat chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). The funding will support studies in dogs and mice to identify a lead formulation with enhanced intestinal permeability and favorable pharmacokinetics, which can then...

This $521,019 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to evaluate and identify the communication between urothelial cells, sensory neurons, and the brain. The grant supports research at the Medical College of Wisconsin, Inc. to functionally and molecularly characterize the sensory neurons that respond to direct stimulation of...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (CFDA 93.279 Drug Use and Addiction Research Programs) will provide $1,516,765 to the University of California, Los Angeles (UCLA) to validate an innovative near infrared spectroscopy (NIRS) technology as a non-invasive method for assessing pelvic floor muscle fitness in patients with myofascial pelvic pain (MPP). The goal is to establish parameters to quantify the severity and spatial patterns of...

The University of California, San Francisco (UCSF) was awarded a $474,043 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) to conduct research on the utilization, outcomes, and complications associated with third-line treatments for refractory overactive bladder (OAB) in older and frail older adults. The study aims to better understand how factors such as age, frailty, race, socioeconomic status, and provider experience impact the use and...

This Project Grant award for $690,451 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The funding supports research at the University of Pittsburgh to investigate the role of bladder fibroblasts, specifically suburothelial fibroblasts (SUFs), in regulating bladder function and sensation. The research aims to determine the molecular mechanisms by which SUFs...