Project Grant R01DK102043

This federal Project Grant award of $984,000 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to test a novel treatment using sodium glucose co-transporter-2 (SGLT-2) inhibitor medications for the prevention of recurrent idiopathic calcium phosphate (CAP) kidney stones. The research, to be conducted at the University of Chicago from September 2025 to September...

This federal Project Grant award of $166,740 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), is focused on defining the role of urinary phosphate in the progression of chronic kidney disease (CKD). The key products and services to be delivered through this 5-year award include: Determining how chronic phosphaturia (excessive urinary phosphate excretion) impacts CKD...

This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), part of the Oral Diseases and Disorders Research (CFDA 93.121) federal grant program, will fund research aimed at understanding the regulation of the calcium transporter SLC24A4 and its role in enamel formation. The $902,000 award to the University of California, San Francisco will support a 2-year investigation into the transcriptional and cellular mechanisms governing SLC24A4 expression in...

This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to investigate the role of urinary urate in regulating renal water homeostasis and its impact on cystogenesis in autosomal dominant polycystic kidney disease (ADPKD). The $2,967,657 grant awarded to Mayo Clinic Jacksonville aims to evaluate how intracellular urate accumulation in...

This federal Project Grant award of $350,000.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award to Katharos, Inc. (UEI: XSTCCEP41DN1) supports the development of a novel extracorporeal technology called the "Phosfilter" device. The goal is to enhance the removal of excess phosphate from the blood of patients with kidney disease on...

This $1,421,456 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research to define cell states in the kidney along the thick ascending limb, distal convoluted tubule, and connecting tubule. The research aims to characterize cell types in these regions, understand how potassium stress, diuretic drugs, water stress, and calcium stress affect...

This Project Grant award of $278,224 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research program) supports the development of a novel, noninvasive "Burst Wave Lithotripsy" (BWL) technology to fragment larger kidney stones. The goal is to expand on prior successful testing of BWL for 10 mm stones to address the 10-20 mm stone range, while addressing key technical challenges around...

This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $225,304 to Northwestern University for research on polycystin proteins and their role in autosomal dominant polycystic kidney disease (ADPKD). The primary goals of this project are to: 1) Characterize the functional consequences of ADPKD disease-causing variants in the PKD2 gene using...

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $414,267 Cooperative Agreement titled "Polycystic Kidney Disease In Vitro Center (PKD-INVENT)" under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The goal of this project is to expand preclinical-to-clinical research for polycystic kidney disease (PKD) by generating products, services, and education focused on human PKD organoids and related cellular systems...

This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) aims to test the safety and efficacy of parathyroid gland allotransplantation for treating chronic hypoparathyroidism. The $317,120 award, granted on August 15, 2025, will support research conducted by the University of California, San Francisco to investigate using normal parathyroid glands from deceased donors as a replacement therapy that could potentially eliminate the...