Project Grant R01DE036286
Award Date 7/21/26
Completion Date 4/30/30
Dollars Obligated $631K
Federal Agency
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
Loma Linda, CA 92354, USA
Similar Awards
- The National Institute of Dental and Craniofacial Research awarded Baylor College of Medicine $453,797 on June 5, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate the structures and functions of natural products in periodontal disease. The funded research centers on a novel biosynthetic gene cluster found in clinical isolates of Porphyromonas gingivalis that appears to encode an antibiotic selective for other P. gingivalis strains and related oral...
- The National Institute of Dental and Craniofacial Research awarded the University of Illinois $320,660 on April 6, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate the immunoregulatory role of dendritic cell subsets in periodontal disease. The award funds research examining how three major dendritic cell subsets—myeloid, lymphoid, and plasmacytoid dendritic cells—respond during periodontal disease resolution and interact functionally with periopathic...
- The National Institute of Dental and Craniofacial Research awarded Virginia Commonwealth University $101,828 on December 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to conduct functional and structural characterization of phospholipase A2 in Porphyromonas gingivalis, a keystone pathogen of periodontitis. The research delineates the biochemical and structural features of the PG1879 enzyme as a phospholipase A2 and determines its role in the pathophysiology of...
- The National Institute of Dental and Craniofacial Research awarded Virginia Commonwealth University $473,186 on September 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to conduct functional characterization of phospholipase A2 enzymes in Porphyromonas gingivalis, a keystone periodontal pathogen. The research interrogates phospholipase A2 (PLA2) homologs identified in P. gingivalis genomes, specifically examining whether bacterial PLA2 enzymes function as conserved...
- The National Institute of Dental and Craniofacial Research awarded the University of Massachusetts Lowell $100,676 on September 30, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop a three-dimensional in vitro human periodontal sulcus tissue model capable of reproducing healthy and disease states of gingivitis and periodontitis. The recipient will engineer a sustained tissue culture system that mimics key anatomical features of the gingival sulcus—including...
- The National Institute of Dental and Craniofacial Research awarded $234,000 to the University of Texas Health Science Center at Houston on September 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate decoy adhesion mechanisms by which the commensal bacterium Veillonella atypica shields oral epithelial cells from colonization and inflammatory damage by the pathogenic keystone species Porphyromonas gingivalis. The research dissects the molecular and...
- The National Institutes of Health National Institute of Dental and Craniofacial Research awarded The Trustees Of The University Of Pennsylvania $521,273 on September 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121). The award funds research into dendritic cell and T cell dysregulation in periodontitis associated with poorly controlled diabetes. The project examines how hyperglycemia reprograms dendritic cells and T cells through epigenetic mechanisms, activating...
- Federal Project Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded University of California, Los Angeles $180,943.00 under the Oral Diseases and Disorders Research program (CFDA 93.121) on June 13, 2025, for research addressing therapeutic targeting of apical periodontal T-cells in chronic oral inflammation. The research initiative, which extends through May 31, 2030, investigates the pathogenic mechanisms underlying apical periodontitis—a chronic...
- The National Institute of Dental and Craniofacial Research, part of the National Institutes of Health within the Department of Health and Human Services, awarded $435,875 to Indiana University Indianapolis on July 15, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate oxylipin-mediated biofilm colonization in peri-implant disease. The research explores the role of oxylipins in regulating bacterial biofilm formation around dental implants. The study aims...
- The National Institute of Dental and Craniofacial Research awarded the University of Illinois $576,957 on September 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop and evaluate nanotherapeutic and immunotherapeutic approaches for periodontal disease targeting inflammatory and osteoclastogenic pathways. The project develops site-specific nanoparticle platforms designed to attenuate disease progression and preserve alveolar bone. Aim 1 evaluates myeloid...