Project Grant R01DE036248
- The National Institute of Dental and Craniofacial Research, part of the Department of Health and Human Services National Institutes of Health, awarded The Washington University $427,625 on February 6, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121). The award funds research to develop and evaluate radiation-guided theranostic agents for detecting and monitoring response to oral cancer treatment. The research leverages radiation-inducible antigens, specifically...
- The National Institute of Dental and Craniofacial Research awarded the University of Rochester $642,037 on August 6, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop and validate SmartTeeth++, an AI-powered digital platform for remote detection and prediction of early-stage oral diseases including dental caries and gingivitis. The project integrates computer vision, machine learning, biomedical engineering, and clinical dentistry to deliver three core...
- The National Institute of Dental and Craniofacial Research awarded the University of Missouri System $304,650 on July 6, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to engineer cell sheets that restore salivary gland function in irradiated mice. The research addresses permanent salivary gland damage caused by radiation therapy for head and neck cancer, for which current treatments—saliva substitutes and secretory agonists—remain largely ineffective. The project...
- The National Institute of Dental and Craniofacial Research, part of the National Institutes of Health under the Department of Health and Human Services, awarded The University of Chicago $328,000 on August 5, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop and validate a microsimulation model of oral health lifetime outcomes and resource use in older adults. The project, titled "Development and Validation of the U.S. Oral Health Microsimulation...
- The National Institute of Dental and Craniofacial Research awarded the University of Southern California $481,739 on September 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop three-dimensional organoid models representing the stepwise neoplastic evolution of head and neck squamous cell carcinoma. The recipient institution will create organoids directly from normal human oral tissues, patient-derived leukoplakia samples, and head and neck squamous cell...
- The National Institute of Dental and Craniofacial Research awarded the University of Arizona $371,900 on August 3, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop innovative methods for evidence synthesis in oral health research. The project addresses barriers in current oral health evidence synthesis by developing oral-health-specific artificial intelligence tools, methodological resources, and analytical approaches. Aim 1 validates and adapts AI tools...
- The National Institute of Dental and Craniofacial Research awarded the University of Texas Health Science Center at Houston $721,776 on July 6, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to establish secure open access to the BIGMOUTH Dental Data Repository and develop an AI-powered research platform. The project, titled "OPENMOUTH: Leveraging AI to Enhance Fairness in Dental Clinical Research," will fully de-identify clinical data from the largest...
- The National Institute of Dental and Craniofacial Research awarded The University of Iowa $815,438 under the Oral Diseases and Disorders Research program on July 15, 2026. The award funds a longitudinal study investigating how a self-determination theory–based psychoeducational intervention affects oral microbial communities and early childhood caries risk factors in children from birth to three years of age. The research will compare oral metagenomic profiles between children receiving the...
- The National Institute of Dental and Craniofacial Research awarded The Regents of the University of Colorado, doing business as University of Colorado-Denver, $656,545 in project grant funding on August 24, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121). The award funds research to characterize the spatial and functional architecture of recurrent oral squamous cell carcinoma by integrating immune cell distribution with bacterial localization, transcriptomics, and...
- The National Institute of Dental and Craniofacial Research awarded the University of Kansas Medical Center Research Institute, Inc. $693,365 on March 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate the role of MK2 protein in head and neck squamous cell carcinoma cell migration, invasion, and metastases. The recipient will examine how tumor MK2 regulates FAK-ITGB4 mediated tumor cell migration and invasion using biotin-ligation proximity labeling...
The National Institute of Dental and Craniofacial Research awarded The Curators of the University of Missouri, doing business as University of Missouri at Kansas City, $527,533 on September 19, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop an AI-driven multimodal imaging system for risk stratification of oral potentially malignant disorders. The award funds development of machine learning and deep learning models that integrate Fourier-transform infrared (FTIR) imaging and histological imaging to predict malignant transformation risk in oral precancerous lesions. The project encompasses three specific aims: development of FTIR imaging-based ML and DL models for risk stratification, development of histological imaging-based DL models for tissue segmentation and risk stratification, and development and validation of multimodal imaging systems combining both techniques. The proposed system is designed for incorporation into existing clinical workflows to enhance precancer diagnosis, facilitate early oral cancer detection, and improve outcomes for patients with oral squamous cell carcinoma precursors. Work is performed in Kansas City, Missouri, with a period of performance extending from September 19, 2026, through June 30, 2030. The assistance type is Project Grant, a direct research award supporting basic, translational, and clinical research in dental, oral, and craniofacial health and disease.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $527.5k | 9/3/26 |