The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $537,163 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) program to The University of Iowa. The 4-year grant, awarded on July 1, 2024, supports research examining the relationship between anesthesia exposure, oxygen levels, brain structure/function, and pre-speech/language development in infants with isolated cleft lip and/or palate (ICL/P). The study involves longitudinal assessments of infants with ICL/P and unaffected controls at 2, 6-8, and 14-16 months of age, utilizing innovative brain imaging techniques (MRI, fNIRS) and multimodal speech/language evaluation. The University of Pittsburgh is a sub-awardee responsible for specific research activities at their site, including enrolling participants, collecting data, and collaborating on data analysis. This research aims to elucidate the etiology of language deficits observed in children with ICL/P and inform clinical interventions to improve neurodevelopmental outcomes.
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