Semiconductor biomaterials to speed bone healing: a bioengineering-driven approach

Active Project Grant Awarded Last action

Award ID
R01DE031872
Recipient
Awarding agency
Obligated
$4,510,526

Award facts

Assistance listing
93.121 Oral Diseases and Disorders Research
Completion date 74% complete
Place of performance
Arlington, TX 76019, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Craniofacial trauma leads to over 10 million emergency room visits per year in the US that cause a vast socio- economic burden. Unlike small defects, large complex defects arising from traumatic avulsive injuries or pathologic lesion resection require planned reconstruction or secondary surgery to regain bony union. Yet, these defects do not spontaneously heal and are known as "critical size defects" (CSD). Attempts to induce bone formation by vascularized autologous grafts led to donor site morbidity and low harvest volume. Further, recombinant human bone morphogenic protein (RHBMP2) growth factor used with autograft often produces harmful inflammation and swelling post-surgery. Alternatively, titanium (TI) fixation plates lend structural support to bony fragments but lack bioactivity to speed healing. Moreover, clinically available mesoporous bioglasstm, FDA-approved polymers, or composite pastes or putties lack needed strength and bioactivity for bone healing. Our goal is to bioengineer new biomaterials that target healing mechanisms for rapid defect repair. Bone healing requires rapid regeneration of dense biomineral and vascular tissue, which depends on antioxidant activity to promote cell migration and osteogenesis by mesenchymal stem cells (MSC) and angiogenesis by endothelial cells (EC). Our objective is to stimulate bone healing by (1) revealing biomaterial chemistries that target MSC and EC antioxidant activity (2) atomistically layer these biomaterials as coatings on TI devices to enhance bone defect healing; and (3) use new nanoparticles (NPS) chemistries embedded in biopolymer scaffolds for rapid defect healing. We created silicon OXY-nitro-phosphide (SIONPX) by chemical vapor deposition as new coatings for TI mesh and nanoparticles (SIONPX-NP) in biopolymer scaffolds that release antioxidant ions (SI4+). We hypothesize that SIONPX enhances dense bone and vascular tissue healing and rapid bone repair via enhanced antioxidant activity to promote angiogenesis and osteogenesis. In aim 1, we will study the effect of SI4+ on the promotion of these antioxidants during mscs osteogenesis and ECS angiogenesis. In aim 2, we will determine the effect of SIONPX coatings to stimulate antioxidant promoters to hasten the local bone healing environment. In aim 3, we will use SIONPX-NP-biopolymer scaffolds to stimulate antioxidant promoters to promote cell migration, angiogenesis, and osteogenesis into scaffold structures to hasten the healing process. Our central innovation is the development of a new class of implantable and printable materials that can accelerate healing of craniofacial bone defects. Once such materials/devices become clinically available, there is the promise that a significant advancement will have been made toward their translation in patients needing rapid healing of large bone defects or fractures. These results will have a positive impact in supporting future clinical trials of new antioxidant materials on biomedical devices that can reduce patient healing time, reduce medical care cost, and increase the quality of newly formed bone in large defects.

Transactions

Action Obligated Date
Amendment $454,596
Amendment $45,459
Amendment $409,138
Amendment $409,138
Amendment $36,533
Amendment $36,533
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Amendment $411,012
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Amendment $479,516
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Original award $479,516
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Subawards

Subrecipient Amount Awarded
William Marsh Rice University The purpose of this amendment is to provide additional funding in the amount of $19,031.00 and to authorize carryover of unobligated balances from period… $61,321
The University Of Texas Health Science Center At Houston $114,903
University Of Texas Health Science Center At Houston Semiconductor Biomaterials to Speed Bone Healing: A Bioengineering-Driven Approach $114,903
William Marsh Rice University $42,290

Quick answers

Who received award R01DE031872?

R01DE031872 was awarded to University Of Texas At Arlington by National Institute of Dental and Craniofacial Research (National Institutes of Health) on March 3, 2023.

How much is award R01DE031872 worth?

$4,510,526 has been obligated on R01DE031872.

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