A miniaturized and high-frequency acoustic imaging system for oral health and diseases of the head and neck
Active Project Grant Awarded Last action
- Award ID
- R01DE031307
- Recipient
-
University Of California, San Diego UEI UYTTZT6G9DT1 Part of State Of California Controllers Office
- Awarding agency
-
National Institute of Dental and Craniofacial Research
National Institutes of Health, Department of Health and Human Services
- Obligated
- $5,079,148
Award facts
- Assistance listing
- 93.121 Oral Diseases and Disorders Research
- Completion date 88% complete
- Funding
-
- $4,415,053.00 Federal
- $664,095.00 Non-federal
- Place of performance
- La Jolla, CA 92093, USA
Award details come from USAspending.gov.
Description
- Abstract
- Periodontitis and oral disease are widespread with major and negative impacts on quality of life. Radiography is the standard of care in imaging but is limited to assessment of hard tissue. In the last three years, we have shown that ultrasound imaging offers significant advantages to oral health including non-invasive and real- time assessment of the periodontal probing depths, cementoenamel junction, gingival thickness, gingival perfusion/hypoxia, and clinical attachment loss. However, further clinical work in this field is limited by the large size of the ultrasound transducers-they are simply too large to access the posterior teeth. While smaller transducers exist, they cannot operate at the high frequency (>40 MHZ) needed to image the small feature sizes involved in oral health. Therefore, we have established a three-way academic-industrial partnership to refine and finalize these devices for oral health. DR. Jokerst at ucsd serves as PI and pioneered the use of photoacoustic imaging in oral health. Visualsonics corp. Is our industrial partner-DR. Jokerst's preliminary data was collected on visualsonics equipment, and this company has a 20-year track record in developing high-frequency transducers including recent 510K-approved systems for human use. The clinical partner is DR. Casey chen who is chair of periodontology at USC and who will validate the system with human subjects. Aim 1 of the work will build and validate a small hockey stick-style transducer. While this design is already common, hockey stick transducers above 20 MHZ are not available. Aim 2 will integrate diode lasers into the system for photoacoustic imaging to complement ultrasound. Aim 3 will develop image-processing algorithms to automatically export metrics of oral health such as clinical attachment loss and probing depth. Such automated image-processing is critical to broad clinical acceptance. Aim 4 will validate this device in healthy and diseased human subjects with comparisons to clinical gold standards. The significance of this work is based on the widespread prevalence of periodontal disease and the remarkable new insight that acoustic imaging offers in diagnosis and treatment planning. The innovative outcomes include non-invasive charting, direct measurements of the cementoenamel junction, noninvasive biotyping, and 3D maps of inflammation near implants. The work is feasible because of the track record of all three partners as well as their history of collaboration. This is a good investment for NIH because there is no miniaturized and high-frequency (>40 MHZ) ultrasound transducer available despite the dramatic improvement in spatial resolution that high frequency offers. The proposal offers deliverables at all ranges of risk and the ultrasound transducer is highly likely to succeed with implications well beyond oral health: applications in endoscopy, head and neck diseases, as well as transrectal/transvaginal imaging are obvious.
Transactions
| Action | Federal | Non-federal | Date |
|---|---|---|---|
| Amendment | $602,262 | $0 | |
| Amendment | $609,858 | $0 | |
| Amendment | $607,357 | $0 | |
| Amendment | $633,693 | $0 | |
| Amendment | $633,693 | $0 | |
| Amendment | $664,095 | $0 | |
| Original award | $664,095 | $664,095 |
Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| Fujifilm Visualsonics Inc. | $561,496 | |
| University Of Southern California | $574,397 |
Quick answers
Who received award R01DE031307?
R01DE031307 was awarded to University Of California, San Diego by National Institute of Dental and Craniofacial Research (National Institutes of Health) on June 21, 2022.
How much is award R01DE031307 worth?
$5,079,148 has been obligated on R01DE031307: $4,415,053 in federal funding and $664,095 in non-federal funding.
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