This Project Grant award, provided by the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), will fund research to investigate the role of vitamin D metabolites in modulating inflammation and improving olfactory function in patients with chronic rhinosinusitis with nasal polyposis (CRSwNP). The $490,075 award, with a period of performance from May 1, 2025 to April 30, 2030, will be used by the University of Florida to: 1) assess the interplay between olfactory loss, vitamin D metabolites, and sinonasal inflammation in CRSwNP patients; 2) determine the mechanisms by which vitamin D metabolites can modulate inflammation in human sinonasal epithelial cells; and 3) evaluate the ability of vitamin D metabolites to improve olfactory loss and reduce inflammatory cell infiltrate in murine models of eosinophilic and neutrophilic chronic rhinosinusitis. This research aims to provide evidence for the potential use of vitamin D as a treatment for CRSwNP-related olfactory dysfunction.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $490.1k | 4/18/25 |