Project Grant R01DC022260
- The National Institute on Deafness and Other Communication Disorders awarded the University of Miami $484,738 on May 1, 2026, for project grant R01DC022861 under the Research Related to Deafness and Communication Disorders program (CFDA 93.173). The award funds development of a human pluripotent stem cell system to study inner ear development and disease. The recipient will engineer a microphysiological system featuring a microfluidic chip to establish precise morphogen concentration...
- The National Institute on Deafness and Other Communication Disorders awarded Creighton University $161,405 on July 1, 2026, under the Research Related to Deafness and Communication Disorders program (CFDA 93.173) to investigate how noise-induced hearing loss alters the auditory efferent system and contributes to central auditory hyperactivity. The research examines lateral olivocochlear neurons, the most abundant efferent neurons responsible for brain-to-ear feedback and hearing protection after...
- The National Institute on Deafness and Other Communication Disorders awarded The Johns Hopkins University $687,094 on February 23, 2026, under the Research Related to Deafness and Communication Disorders program (CFDA 93.173) to investigate mechanisms of hair cell mechanotransduction and the protein defects that cause deafness. The recipient will use genetically modified organisms combined with biochemical, cell biological, and electrophysiological methods to study how mechanical force regulates...
- The National Institute on Deafness and Other Communication Disorders awarded the University of Pittsburgh $659,250 on May 7, 2026, under the Research Related to Deafness and Communication Disorders program (CFDA 93.173). The award funds research into critical proteins regulating mechanotransduction channel trafficking and localization in cochlear hair cells, which are essential for converting sound waves into electrical signals and maintaining auditory function. The research addresses how...
- The National Institute on Deafness and Other Communication Disorders (NIDCD), part of the National Institutes of Health, awarded The Washington University $557,999 on September 1, 2026, under the Research Related to Deafness and Communication Disorders program (CFDA 93.173). The award funds investigation of how inner hair cells in the cochlea encode sound frequency and intensity across a wide dynamic range. The research employs in vivo two-photon cochlear imaging integrated with single-cell...
- The National Institute on Deafness and Other Communication Disorders awarded Massachusetts Eye and Ear Infirmary $1.15 million on August 15, 2026, under the Research Related to Deafness and Communication Disorders program (CFDA 93.173) to conduct an IND-enabling study of AAV-mediated TMPRSS3 gene therapy for autosomal recessive hearing loss DFNB8. The recipient will develop and validate preclinical evidence supporting an investigational new drug application for TMPRSS3 gene therapy in a mouse...
- This federal Project Grant award of $448,687, provided by the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), supports research to investigate the role of calcium regulation in outer hair cells (OHCs) and their sensitivity to cochlear injury. The research aims to enhance understanding of the mechanisms that protect OHCs, which act as sentinels of cochlear injury, from damage due...
- The National Institute on Deafness and Other Communication Disorders awarded the University of Washington $490,487 on February 13, 2026, under the Research Related to Deafness and Communication Disorders program (CFDA 93.173) to study spatial patterning in the zebrafish inner ear and its relevance to vestibular dysfunction in humans. The project investigates how hair cells in vestibular organs establish distinct central and peripheral regions with conserved functional and molecular identities...
- The National Institute on Deafness and Other Communication Disorders awarded The University of Chicago $451,000 on August 24, 2026, under the Research Related to Deafness and Communication Disorders program (CFDA 93.173) to develop a native biochemical preparation of the mechanotransduction complex (METC) from cnidarian nematocytes as a model of vertebrate hair-cell function. The award funds research into the structural dynamics and functional mechanisms of the METC, the cellular machinery...
- The National Institute on Deafness and Other Communication Disorders awarded $1,987,881 to The Regents of the University of Colorado, doing business as University of Colorado-Denver, on April 1, 2026, under the Research Related to Deafness and Communication Disorders program (CFDA 93.173). The award funds a three-year research project investigating age-related demyelination in the auditory brainstem as a mechanism underlying central hearing loss in presbycusis. The research will experimentally...
The National Institute on Deafness and Other Communication Disorders, a component of the Department of Health and Human Services National Institutes of Health, awarded Creighton University $350,000 on July 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) for Project Grant R01DC022260. The award funds investigation of POU4F3, a transcription factor essential for sensory hair cell differentiation, survival, and regeneration. Mutations in POU4F3 cause autosomal dominant hearing loss (DFNA15), estimated to account for 2.5 percent of autosomal dominant hearing loss cases. Using animal models, the research will characterize POU4F3 distal enhancers and their inactivation during hair cell maturation; reveal molecular mechanisms underlying POU4F3 haploinsufficiency-induced hearing loss; and test efficacy of strategies for delivering and regulating exogenous POU4F3 gene to compensate for mutant alleles and preserve hearing. Work is performed in Omaha, Nebraska. The period of performance extends through June 30, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $350.0k | 7/22/26 |