Dynamic circuit motifs underlying multimodal interactions in primate auditory cortex

Active Project Grant Awarded Last action

Award ID
R01DC019979
Recipient
Awarding agency
Obligated
$6,111,461

Award facts

Completion date 86% complete
Funding
  • $5,413,258.00 Federal
  • $698,203.00 Non-federal
Place of performance
Orangeburg, NY 10962, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
There is a strong movement within the neuroscience community towards studying the brain under naturalistic conditions, in rich multisensory paradigms and in the context of behaviors observed in natural environments, such as free viewing. This requires transforming our traditional data collection and analysis pipelines, and their underlying theoretical frameworks. Instead of focusing on one specific system supporting a particular brain function, we must conduct multisite recordings targeting multiple, reciprocally connected circuits, which is the main motivation for our project. Fortunately, this is now technically feasible in both human and nonhuman primates. The overarching goal of our project is to define information transmitting ("driving") VS. "modulatory" circuits of the auditory system. The rationale for this goal is that if only driving circuits existed in the brain, we would not have the ability to focus on behaviorally relevant aspects of our environment. From this perspective, modulatory circuits play as an important role in brain operations as information transmitting ones. Specifically, our project will explore the interaction of four domains of brain function and the distinctive, dynamic circuit motifs (circuits and their spectrotemporal neuronal activity patterns) that underlie them. These brain functions are auditory perception, multisensory interactions within the auditory system, motor sampling of the environment (eye movements), and memory recall. We will utilize electrophysiological recordings during behavioral experiments in non-human and human primates, with computational modeling to bridge the GAP between different recording scales (single unit to EEG), and species (non-human primate VS. Human). Computational models will also be used to suggest specific target nodes and patterns of the distinct circuits for neuromodulation. Using the spectrotemporal neuronal activity (a key feature of a dynamic circuit motif) and model prediction based intracranial electrical brain stimulation, we will verify each identified circuit's causal role in producing its unique circuit motifs and in supporting different aspects of behavior.

Transactions

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Subawards

Subrecipient Amount Awarded
The Feinstein Institutes For Medical Research Dynamic circuit motifs underlying multimodal interactions in primate auditory cortex $211,269
The Feinstein Institutes For Medical Research Dynamic circuit motifs underling multimodal interactions in primate auditory cortex $211,269
The Feinstein Institutes For Medical Research $210,558

Quick answers

Who received award R01DC019979?

R01DC019979 was awarded to Research Foundation For Mental Hygiene, Inc. by National Institute on Deafness and Other Communincation Disorders (National Institutes of Health) on September 16, 2022.

How much is award R01DC019979 worth?

$6,111,461 has been obligated on R01DC019979: $5,413,258 in federal funding and $698,203 in non-federal funding.

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