Project Grant R01DA065573
- The National Institutes of Health Office of the Director awarded The Regents of the University of California, San Francisco $1,639,996 on August 1, 2026, under the Family Smoking Prevention and Tobacco Control Act Regulatory Research program (CFDA 93.077). The award funds a clinical pharmacology study of oral nicotine pouches (ONPs)—small microfiber sachets filled with purified or synthetic nicotine and typically flavored. The research will examine nicotine exposure and subjective effects from...
- The National Institute on Drug Abuse awarded the Board of Regents of the University of Nebraska $422,125 on July 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to examine oral nicotine pouch use and health effects among adolescents and young adults. The recipient, through its University of Nebraska Medical Center division in Omaha, Nebraska, will harmonize nationally representative population assessment data from the PATH Study waves 7–9 (2022–2025) to investigate oral...
- The National Institute on Drug Abuse awarded Rutgers The State University of New Jersey (doing business as RBHS-School of Nursing) $2,107,844 on September 15, 2025, under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct a longitudinal mixed-methods study of nicotine pouch adoption and use patterns among U.S. adults. The research combines a nationally representative longitudinal survey with qualitative interviews to examine who uses nicotine pouches, reasons for adoption,...
- The National Cancer Institute awarded the Board of Regents of the University of Nebraska, through its University of Nebraska Medical Center division, $179,403 on August 1, 2026, under the Cancer Cause and Prevention Research program (CFDA 93.393) to examine longitudinal effects of nicotine pouch use on tobacco use behaviors, biomarkers, and nicotine dependence among U.S. adults. The research will harmonize nationally representative population assessment data from the PATH (Population...
- The National Institute on Drug Abuse awarded the University of Pittsburgh $700,254 on June 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to examine how combined nicotine and opioid exposure alters the prefrontal cortex in opioid use disorder. The research addresses the gap between current OUD treatments and patient outcomes, particularly the role of nicotine dependence as a confounding factor. Between 80–90 percent of individuals with OUD smoke, yet smoking...
- The National Institute of Dental and Craniofacial Research awarded Health Research, Inc. (Roswell Park Division) $347,000 on July 8, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to conduct a large-scale population-based study examining how the use of reduced-exposure nicotine products—electronic nicotine products and oral nicotine pouches—impacts oral health conditions among adults who formerly used combustible or smokeless tobacco in the United States. The research...
- The Department of Health and Human Services National Institutes of Health Office of the Director awarded Health Research, Inc. Roswell Park Division (doing business as Health Research At Roswell Park) $867,448 under the Family Smoking Prevention and Tobacco Control Act Regulatory Research program (CFDA 93.077) on August 1, 2026. The recipient will conduct research assessing whether use of fruit-flavored electronic nicotine delivery systems (ENDS) relates to smoking reductions in people who smoke...
- The National Cancer Institute awarded The Ohio State University $662,436 on August 14, 2026, under the Cancer Cause and Prevention Research program (CFDA 93.393) to design tiered tax rates for electronic cigarettes based on their appeals to youth and young adults. The project addresses evidence gaps in electronic cigarette taxation policy. Specifically, it examines how tiered excise taxes—which impose higher tax rates on electronic cigarettes with youth-appealing features such as flavor, product...
- The National Institute on Drug Abuse awarded Virginia Commonwealth University $1,182,810 under the Drug Use and Addiction Research Programs (CFDA 93.279) on July 15, 2026, to identify and characterize non-nicotine compounds in electronic nicotine delivery systems that drive abuse liability through functional activity at nicotinic acetylcholine receptor subtypes. The award funds high-throughput screening methods to comprehensively identify pharmacologically active non-nicotine constituents in...
- The National Institute on Drug Abuse awarded the Board of Regents of Nevada System of Higher Education, operating as University of Nevada, Reno, $1.903 million on September 15, 2025, under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct a human laboratory study examining how "natural" descriptor marketing on cigarillos influences user expectancies, subjective effects, smoking behavior, and nicotine and toxicant exposure among young adults. The research addresses a...
The National Institutes of Health Office of the Director awarded The Ohio State University $773,576 on August 1, 2026, under the Family Smoking Prevention and Tobacco Control Act Regulatory Research program (CFDA 93.077) to conduct research on oral nicotine pouches and their abuse liability. The research will investigate how freebase nicotine fraction and moisture content in oral nicotine pouches affect the speed of nicotine delivery to users and how acute laboratory measures of abuse liability predict long-term switching outcomes from cigarettes. The study will conduct a double-blind trial among 240 cigarette smokers across two phases, using investigational oral nicotine pouches with equivalent flavors and total nicotine content but varying freebase nicotine fraction (70 percent low) and percent moisture (35 percent low). Researchers will measure both objective markers such as plasma nicotine delivery and subjective measures such as craving relief, and will test whether standardized versus ad libitum use patterns predict switching success. The findings are intended to inform federal regulation of oral nicotine pouches by identifying which abuse liability measures best translate to prospective switching behaviors. Work is performed at The Ohio State University in Columbus, Ohio. The period of performance runs from August 1, 2026, through July 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $773.6k | 7/29/26 |