Project Grant R01CA309279
- The National Institute on Drug Abuse awarded Virginia Commonwealth University $657,471 on September 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to assess the abuse liability of 6-methyl nicotine, a synthetic nicotine analog used in electronic nicotine delivery systems. The research addresses the regulatory gap created by manufacturers using synthetic nicotine analogs to circumvent nicotine-focused regulations, particularly as ENDS use remains the most prevalent form...
- The National Institutes of Health National Cancer Institute awarded The Medical University of South Carolina $586,018 on July 10, 2026, under the Cancer Cause and Prevention Research program (CFDA 93.393) to conduct a three-arm clinical trial testing augmented doses of nicotine replacement therapy for individuals who use both combustible cigarettes and e-cigarettes and wish to quit both products. The trial will randomize dual-use participants to receive behavioral support combined with...
- The National Cancer Institute awarded the Board of Regents of the University of Nebraska, through its University of Nebraska Medical Center division, $179,403 on August 1, 2026, under the Cancer Cause and Prevention Research program (CFDA 93.393) to examine longitudinal effects of nicotine pouch use on tobacco use behaviors, biomarkers, and nicotine dependence among U.S. adults. The research will harmonize nationally representative population assessment data from the PATH (Population...
- The National Cancer Institute awarded the Regents of the University of Minnesota $621,549 under the Cancer Cause and Prevention Research program (CFDA 93.393) on June 1, 2026. The award funds a randomized experimental marketplace study evaluating nicotine pouches as a potential substitute for combustible menthol cigarettes in the context of menthol flavor bans. The research specifically examines the acceptability of nicotine pouches relative to medicinal nicotine among menthol cigarette smokers,...
- The National Institute on Drug Abuse awarded Virginia Commonwealth University $1,182,810 under the Drug Use and Addiction Research Programs (CFDA 93.279) on July 15, 2026, to identify and characterize non-nicotine compounds in electronic nicotine delivery systems that drive abuse liability through functional activity at nicotinic acetylcholine receptor subtypes. The award funds high-throughput screening methods to comprehensively identify pharmacologically active non-nicotine constituents in...
- The Department of Health and Human Services National Institutes of Health Office of the Director awarded Health Research, Inc. Roswell Park Division (doing business as Health Research At Roswell Park) $867,448 under the Family Smoking Prevention and Tobacco Control Act Regulatory Research program (CFDA 93.077) on August 1, 2026. The recipient will conduct research assessing whether use of fruit-flavored electronic nicotine delivery systems (ENDS) relates to smoking reductions in people who smoke...
- The National Institutes of Health awarded Health Research, Inc. (Roswell Park Division) $830,722 on August 15, 2026, under the Family Smoking Prevention and Tobacco Control Act Regulatory Research program (CFDA 93.077) to assess the respiratory effects of inhaling synthetic coolants used as flavor ingredients in electronic nicotine delivery systems. The project will evaluate pulmonary function and inflammatory effects resulting from inhalation of the synthetic coolants WS-3 and WS-23, which...
- The National Cancer Institute awarded the Board of Regents of the University of Nebraska, through its University of Nebraska Medical Center division, $948,630 under the Cancer Cause and Prevention Research program (CFDA 93.393) on August 1, 2026, for a naturalistic cohort study examining the real-world effectiveness of smoking cessation aids in US adults. The project will conduct a longitudinal survey study using the Understanding America Study, a nationally representative panel of 20,000 US...
- The National Institutes of Health Office of the Director awarded The Regents of the University of California, San Francisco $1,639,996 on August 1, 2026, under the Family Smoking Prevention and Tobacco Control Act Regulatory Research program (CFDA 93.077). The award funds a clinical pharmacology study of oral nicotine pouches (ONPs)—small microfiber sachets filled with purified or synthetic nicotine and typically flavored. The research will examine nicotine exposure and subjective effects from...
- The National Heart Lung and Blood Institute awarded the Regents of the University of Michigan $234,000 on September 1, 2026, under the Family Smoking Prevention and Tobacco Control Act Regulatory Research program (CFDA 93.077, Assistance Listing 93.077) to examine how the duration of electronic nicotine delivery systems (ENDS) use affects cardiopulmonary health outcomes among adults with current or former cigarette smoking histories. The research leverages prospective, nationally...
The National Cancer Institute awarded the University of Rochester $583,304 on August 13, 2026, under the Cancer Cause and Prevention Research program (CFDA 93.393) to investigate toxicological assessment of emerging nicotine analogs in electronic nicotine delivery systems (ENDS). The research addresses a substantial knowledge gap regarding the safety profile of novel nicotine analogs, including 6-methyl nicotine and nicotinamide, which manufacturers have introduced to circumvent premarket tobacco product application requirements. No inhalation exposure studies have evaluated these analogs against conventional ENDS products. The award funds investigation into how device wattage, coil materials, coil resistance (sub-ohm to high-ohm), and different nicotine types affect delivery of harmful and potentially harmful constituents. The study hypothesizes that emerging nicotine analog-containing products generate more harmful chemicals than tobacco-derived or synthetic nicotine, inducing toxicity through reactive oxygen species and aldehyde-induced protein carbonylation, with downstream effects on epithelial permeability and inflammation. The research is performed at the University of Rochester, Rochester, New York. The project period extends through July 31, 2031. The award is structured as a Project Grant, the standard assistance type for investigator-initiated research under NCI's Cancer Cause and Prevention Research portfolio.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $583.3k | 8/13/26 |