Project Grant R01CA307001
- The National Cancer Institute awarded Trustees of Dartmouth College $100,228 on February 14, 2027, under the Cancer Research Manpower program (CFDA 93.398) to develop absolute quantitative oxygen-enhanced MRI (AQOE-MRI), a method combining an FDA-approved oxychip electron paramagnetic resonance spin probe with relaxometry measurements to generate absolute PO2 values for mapping tumor hypoxia and guiding radiation therapy dose escalation. The project runs through August 16, 2028, and is performed...
- The National Cancer Institute awarded Trustees of Dartmouth College $509,906 on August 1, 2026, under the Cancer Cause and Prevention Research program (CFDA 93.393) to investigate information preferences, risk perceptions, and tradeoffs in multi-cancer early detection (MCED) decisions through a randomized vignette trial. The research addresses the clinical challenge that MCED tests—emerging blood-based screening tools capable of detecting up to 50 cancer types—have modest positive predictive...
- The National Cancer Institute awarded the University of California, Davis $409,141 on June 1, 2026, under the Cancer Detection and Diagnosis Research program (CFDA 93.394) to develop contrast-enhanced perfusion CT imaging as an alternative to current liver radioembolization workup procedures. The project addresses imaging optimization for selective internal radiation therapy (SIRT), a catheter-based treatment for liver cancer using radioactive yttrium-90 microspheres. Current clinical practice...
- The National Cancer Institute awarded $1,008,660 to Aim Medical Robotics Inc. on September 1, 2026, under the Cancer Detection and Diagnosis Research program (CFDA 93.394) to develop and validate a commercial-grade MRI-compatible neurosurgical robotic system for minimally invasive laser interstitial thermal therapy (LITT) treatment of brain tumors. Aim Medical Robotics is refining and validating the AIM Robotic System, a compact robotic platform designed to complete the full LITT workflow...
- This Department of Defense (CFDA 12.420 - Military Medical Research and Development) Project Grant award of $2,499,990.00 was provided to the Dartmouth-Hitchcock Clinic, doing business as Dartmouth-Hitchcock Obligated Group, to conduct a multicenter randomized controlled trial evaluating the use of incisional negative pressure wound therapy to reduce infection and complications in high-risk fractures. The grant has an award date of September 1, 2023 and an ultimate completion date of August...
- The National Cancer Institute awarded the University of Vermont & State Agricultural College $595,012 on April 13, 2026, under the Cancer Detection and Diagnosis Research program (CFDA 93.394) to develop an integrated image-enabled computational model for lung cancer intratumoral cisplatin therapy. The award is classified as a Project Grant. The funded work advances a computational dosing model that uses tumor volume and morphology to optimize direct intratumoral delivery of cisplatin to...
- The National Institute of Neurological Disorders and Stroke awarded Dartmouth-Hitchcock Clinic $426,250 on July 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate translaminar interneurons in the spinal cord dorsal horn and their role in the transition from acute to chronic pain. The research combines voltage imaging, electrophysiological, and histological strategies to study excitatory translaminar interneurons in...
- The National Cancer Institute, a component of the Department of Health and Human Services, awarded $644,423 to Sloan-Kettering Institute for Cancer Research on June 18, 2026, under the Cancer Treatment Research program (CFDA 93.395). The recipient will develop short-wave infrared (SWIR) Cerenkov luminescence imaging (SWIR-CLI) to visualize the distribution of therapeutic radiotracers and improve monitoring of targeted radiotherapy. Current Cerenkov luminescence imaging requires light-tight...
- Federal Project Grant Award Summary Award Overview The Defense Health Agency (DHA) awarded Dartmouth-Hitchcock Clinic a Project Grant of $5,163,060 under the Military Medical Research and Development program (CFDA 12.420) for research titled "Therapeutic Targeting of the Tumor Microenvironment in Triple-Negative Breast Cancer Patients at High Risk of Relapse and Preclinical Models of Lung Metastases." The award was issued on May 15, 2025, with a performance period extending through May...
- The National Cancer Institute awarded Northeastern University $1,144,692 on September 1, 2026, under the Cancer Detection and Diagnosis Research program (CFDA 93.394) for precision cancer microsurgery using laser ablation-cooling with pulse bursts. The project develops a novel handheld microsurgical device that integrates video cellular-resolution microendoscopy with high-speed pulsed laser ablation to enable rapid visualization and eradication of microscopic tumor deposits at surgical margins...
The National Cancer Institute awarded Dartmouth-Hitchcock Clinic $633,819 on September 1, 2026, under the Cancer Detection and Diagnosis Research program (CFDA 93.394) to develop and validate advanced imaging techniques for laser interstitial thermal therapy (LITT) in the treatment of spinal metastases. The project addresses two critical technical barriers limiting clinical adoption of LITT for spinal tumors: inaccuracies in MRI thermometry caused by motion artifacts from respiration and cardiac pulsation, and difficulty in precise laser fiber placement due to limited soft tissue contrast in conventional low-dose CT image guidance systems. Dartmouth-Hitchcock will develop MRI thermometry methods to compensate for motion artifacts and improve real-time temperature monitoring during LITT, and will create a novel MRI-based image guidance system to enable accurate laser fiber placement. The research team will validate these advancements using motion phantoms and a porcine model of spinal metastases. Performance occurs in Lebanon, New Hampshire, with the project period running through August 31, 2031. The award is structured as a Project Grant, the standard NIH assistance type for individual research projects evaluated on scientific merit and program relevance.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $633.8k | 8/13/26 |