Enhancing the efficacy of radiation by spatially restricting anti-tgfb treatment to the tumor
Active Project Grant Awarded Last action
- Award ID
- R01CA293806
- Recipient
-
Providence Health & Services - Oregon UEI H3R1MLL2VLT7
- Awarding agency
-
National Cancer Institute
National Institutes of Health, Department of Health and Human Services
- Obligated
- $1,171,952
Award facts
- Assistance listing
- 93.395 Cancer Treatment Research
- Completion date 31% complete
- Place of performance
- Portland, OR 97213, USA
Award details come from USAspending.gov.
Description
- Abstract
- Self-renewing stem-like CD8+ t cells (tstem-like), defined by expression of transcription factor TCF1/LEF, dwell in lymphoid tissues and are critical for anti-tumor immune responses. The role of tstem-like cells in local and distant radiation response has not been defined. Preliminary single-cell RNA sequencing data demonstrates tstem-like cells expand to repopulate the tumor within 3 days of radiation. In our first aim we will determine whether tstem- like cells from the tumor-draining lymph node are required for radiation response. Radiation and transforming growth factor beta (tgfβ) inhibition are a promising therapeutic combination. However, tgfβ has opposing effects in anti-tumor CD8+ t cell differentiation, supporting tstem-like cells in the tumor-draining lymph node, while simultaneously promoting exhaustion of tumor-infiltrating CD8+ t cells. In aims 2 and 3, we will test radiation with 2ND generation tgfβ targeting therapeutics that spatially restrict the activity to the tumor microenvironment and relatively spare the tumor-draining lymph node, to determine whether spatial restriction of tgfβ inhibition is able to preserve tstem-like cells and thereby enhance the efficacy of combination therapy.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $585,976 | |
| Original award | $585,976 |
Quick answers
Who received award R01CA293806?
R01CA293806 was awarded to Providence Health & Services - Oregon by National Cancer Institute (National Institutes of Health) on April 1, 2025.
How much is award R01CA293806 worth?
$1,171,952 has been obligated on R01CA293806.
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