Microbial and host biomarkers in colorectal cancer oncogenesis
Active Project Grant Awarded Last action
- Award ID
- R01CA292464
- Recipient
-
The Trustees Of Columbia University In The City Of New York UEI QHF5ZZ114M72
- Awarding agency
-
National Cancer Institute
National Institutes of Health, Department of Health and Human Services
- Obligated
- $1,185,093
Award facts
- Assistance listing
- 93.396 Cancer Biology Research
- Completion date 32% complete
- Place of performance
- New York, NY 10032, USA
Award details come from USAspending.gov.
Description
- Abstract
- Colorectal cancer (CRC) is the second leading cause of cancer death in the U.S. Fusobacterium nucleatum (FN), a gram-negative oral anaerobe, is one of the most prevalent species implicated in CRC. Our previous work demonstrated that FN stimulates colorectal cancer growth via its unique adhesin fada, which binds E-cadherin and activates WNT/?-catenin signaling. Fada undergoes dramatic biochemical changes to become amyloid-like under stress and disease conditions, converting FN from a benign commensal to a virulent pathogen. Amyloid fada preferentially binds to cells expressing annexin A1 (ANXA1), which is upregulated in proliferating CRC cells and is critical for CRC growth. Upon binding to CRC cells, FN further stimulates ANXA1 expression via amyloid fada worsening prognosis. We hypothesize that amyloid-like fada and ANXA1 are novel biomarkers in CRC oncogenesis. To test this hypothesis, we propose the following interrelated aims: (I) mechanistic and therapeutic investigation of amyloid-like fada in CRC; and (II) mechanistic and therapeutic investigation of ANXA1 in CRC. Results from this study will significantly advance our understanding of microbes in CRC and identify potential therapies, thus will have tremendous translational potential.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $584,594 | |
| Original award | $600,499 |
Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| A New Jersey Nonprofit Corporation Hackensack Meridian School Of Medicine | $41,027 |
Quick answers
Who received award R01CA292464?
R01CA292464 was awarded to The Trustees Of Columbia University In The City Of New York by National Cancer Institute (National Institutes of Health) on April 1, 2025.
How much is award R01CA292464 worth?
$1,185,093 has been obligated on R01CA292464.
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